Literature summary extracted from

Lee, S.J.; Konishi, Y.; Yu, D.T.; Miskowski, T.A.; Riviello, C.M.; Macina, O.T.; Frierson, M.R.; Kondo, K.; Sugitani, M.; Suvar, J.C.; Blazejewski, K.M.
Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities (1995), J. Med. Chem., 38, 3547-3557.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
5.3.99.5	4-(Benzylamino)-2-(3'-pyridyl)quinazoline	-	Homo sapiens
5.3.99.5	4-(Benzylamino)-2-(imidazol-1-yl)-quinazoline	-	Homo sapiens
5.3.99.5	Sodium 5-(3'pyridinylmethyl)benzofuran-2-carboxylate	-	Homo sapiens

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.5	Homo sapiens	-	-	-
5.3.99.5	Rattus norvegicus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.3.99.5	platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.5	Prostaglandin H2	i.e. PGH2	Homo sapiens	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	-	?
5.3.99.5	Prostaglandin H2	i.e. PGH2	Rattus norvegicus	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)