BRENDA - Enzyme Database show

Effects of high glucose concentration and a thromboxane synthase inhibitor on the production of thromboxane A2 and prostaglandin I2 and E2 by cultured retinal endothelial cells

Sone, H.; Okuda, Y.; Kawakami, Y.; Yamashita, K.; Life Sci. 58, 239-243 (1996)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
5Z-6[(2S,4R)-4-(4-Chlorophenylsulfonylamino)-1-(3-pyridylmethyl)-2-pyrrolidinyl]-5-hexenoic acid
causes marked improvement in the PGI2/TXA2 ratio in diabetic retinopathy by inhibition of thromboxane synthase
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Bos taurus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3184
Bos taurus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
5Z-6[(2S,4R)-4-(4-Chlorophenylsulfonylamino)-1-(3-pyridylmethyl)-2-pyrrolidinyl]-5-hexenoic acid
causes marked improvement in the PGI2/TXA2 ratio in diabetic retinopathy by inhibition of thromboxane synthase
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3184
Bos taurus
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
-
-
-
-