BRENDA - Enzyme Database show

Biosynthesis of thromboxanes in human platelets. I. Characterization and assay of thromboxane synthetase

Sun, F.F.; Biochem. Biophys. Res. Commun. 74, 1432-1440 (1977)

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
9,11(Epoxymethano) prostanoic acid
-
Homo sapiens
5.3.99.5
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
weak
Homo sapiens
5.3.99.5
additional information
the enzyme is not affected by nonsteroidal antiinflammatory agents
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Homo sapiens
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3182
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
thromboxane A2 is an intermediate
3182
Homo sapiens
-
pH Range
EC Number
pH Minimum
pH Maximum
Commentary
Organism
5.3.99.5
5
8.5
very little pH-dependence between pH 5-8.5, above pH 9.0 the reaction is significantly depressed
Homo sapiens
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
9,11(Epoxymethano) prostanoic acid
-
Homo sapiens
5.3.99.5
9alpha,11alpha-Methanoepoxy-15(S)-hydroxyprosta-5(cis)-13(trans)-dienoic acid
weak
Homo sapiens
5.3.99.5
additional information
the enzyme is not affected by nonsteroidal antiinflammatory agents
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Homo sapiens
-
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
Prostaglandin H2
i.e. PGH2
3182
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
thromboxane A2 is an intermediate
3182
Homo sapiens
-
pH Range (protein specific)
EC Number
pH Minimum
pH Maximum
Commentary
Organism
5.3.99.5
5
8.5
very little pH-dependence between pH 5-8.5, above pH 9.0 the reaction is significantly depressed
Homo sapiens