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Literature summary extracted from
- On the inhibitory potency of imidazole and its derivatives on thromboxane synthetase (1978), Biochem. Biophys. Res. Commun., 80, 236-242.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.5 | 1-(2-Isopropylphenyl)-imidazole | strong | Homo sapiens |  |
| 5.3.99.5 | 1-Decylimidazole | strong | Homo sapiens | |
| 5.3.99.5 | 1-Nonylimidazole | strong | Homo sapiens | |
| 5.3.99.5 | imidazole | and derivatives. The potency of 1-substituted imidazoles is increased as the side chain becomes more hydrophobic. Inhibition is competitive with respect to prostaglandin endoperoxide substrate | Homo sapiens | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.5 | microsome | - |
Homo sapiens | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.5 | platelet | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.5 | Prostaglandin H2 | i.e. PGH2 | Homo sapiens | thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid | - |
? | |
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Release 2023.1 (January 2023)
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