BRENDA - Enzyme Database show

Inhibition and properties of thromboxane synthetase

Hammarstroem, S.; Diczfalusy, U.; Adv. Inflamm. Res. 1, 431-438 (1979)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
1(omega-Carboxylalkyl)imidazoles
very potent
Homo sapiens
5.3.99.5
1-Methyl imidazole
-
Homo sapiens
5.3.99.5
2-Isopropyl-3-nicotinylindole
-
Homo sapiens
5.3.99.5
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
i.e. N-0164
Homo sapiens
5.3.99.5
9,11(Epoxymethano) prostanoic acid
-
Homo sapiens
5.3.99.5
9,11-Azo-15-hydroxyprosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
9,11-Azoprosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
9,11-Epoxymethano-15-hydroxy-prosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
Benzydamine
-
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Homo sapiens
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.5
Homo sapiens
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
5.3.99.5
partial
Homo sapiens
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
2 prostaglandin G2
i.e. PGG2
3175
Homo sapiens
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3175
Homo sapiens
-
5.3.99.5
prostaglandin H1
-
3175
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
+ malondialdehyde
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1
3175
Homo sapiens
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
5.3.99.5
1(omega-Carboxylalkyl)imidazoles
very potent
Homo sapiens
5.3.99.5
1-Methyl imidazole
-
Homo sapiens
5.3.99.5
2-Isopropyl-3-nicotinylindole
-
Homo sapiens
5.3.99.5
4-{2-[(4-chlorophenyl)methyl]-3-phenylpropanoyl}phenyl hydrogen benzylphosphonate
i.e. N-0164
Homo sapiens
5.3.99.5
9,11(Epoxymethano) prostanoic acid
-
Homo sapiens
5.3.99.5
9,11-Azo-15-hydroxyprosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
9,11-Azoprosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
9,11-Epoxymethano-15-hydroxy-prosta-5,13-dienoic acid
-
Homo sapiens
5.3.99.5
Benzydamine
-
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.5
microsome
-
Homo sapiens
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
5.3.99.5
partial
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.5
platelet
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.5
2 prostaglandin G2
i.e. PGG2
3175
Homo sapiens
15-hydroperoxythromboxane B2 + 12-hydroperoxy-5,8,10-heptadecatrienoic acid
-
3175
Homo sapiens
-
5.3.99.5
prostaglandin H1
-
3175
Homo sapiens
12(L)-hydroxy-8,10-heptadecadienoic acid + thromboxane B1
thromboxane B1 is scarcely detectable, the major product is 12(L)-hydroxy-8,10-heptadecadienoic acid
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
the thromboxane A2 that is formed by the enzyme is transformed to thromboxane B2
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
+ malondialdehyde
3175
Homo sapiens
-
5.3.99.5
Prostaglandin H2
i.e. PGH2
3175
Homo sapiens
Thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid
the ratio of thromboxane to C17 hydroxyfatty acid formation is 1:1
3175
Homo sapiens
-