Literature summary extracted from

Hecker, M.; Baader, W.J.; Weber, P.; Ullrich, V.
Thromboxane synthase catalyses hydroxylations of prostaglandin H2 analogs in the presence of iodosylbenzene (1987), Eur. J. Biochem., 169, 563-569.

Organism

EC Number	Organism	UniProt	Comment	Textmining
5.3.99.5	Homo sapiens	-	-	-

Reaction

EC Number	Reaction	Comment	Organism	Reaction ID
5.3.99.5	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9alpha,11alpha-epoxy-15-hydroxythromboxa-5,13-dienoate	role of the thiolate ligand in the oxygen activation mechanism	Homo sapiens	a

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
5.3.99.5	platelet	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5.3.99.5	15(S)-Hydroxy-11alpha,9alpha-epoxymethano-5(Z),13(E)-prostadienoic acid	in presence of iodosylbenzene	Homo sapiens	?	3 different hydroxylated derivatives of 15(S)-hydroxy-11alpha,9alpha-epoxymethano-5(Z),13(E)-prostadienoic acid	?
5.3.99.5	Prostaglandin H2	i.e. PGH2	Homo sapiens	thromboxane B2 + 12(L)-hydroxy-5,8,10-heptadecatrienoic acid	-	?

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Release 2023.1 (January 2023)