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Literature summary extracted from
- Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells (1994), J. Biol. Chem., 269, 18275-18278.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 3.4.24.71 | expressed in COS-cells | Rattus norvegicus |
| 3.4.24.71 | rat | Rattus norvegicus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.71 | additional information | no inhibition by thiorphan, captopril | Rattus norvegicus | |
| 3.4.24.71 | phosphoramidon | - |
Rattus norvegicus |  |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.24.71 | membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.71 | Zinc | zinc metalloproteinase, zinc-binding domain | Rattus norvegicus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.71 | 85520 | - |
rat, deduced from nucleotide sequence | Rattus norvegicus |
| 3.4.24.71 | 86000 | - |
1 * 86000, deglycosylated enzyme, SDS-PAGE | Rattus norvegicus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.71 | glycoprotein | highly glycosylated with 10 possible N-linked glycosylated sites | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.71 | endothelium | vascular | Rattus norvegicus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.71 | Human big endothelin 1 + H2O | best substrate | Rattus norvegicus | Endothelin 1 + big endothelin 1(21-38) | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.71 | monomer | 1 * 86000, deglycosylated enzyme, SDS-PAGE | Rattus norvegicus |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.71 | 37 | - |
assay at | Rattus norvegicus |
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