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Literature summary extracted from

  • Kleiber, J.; Kalousek, F.; Swaroop, M.; Rosenberg, L.E.
    The general mitochondrial matrix processing protease from rat liver: structural characterization of the catalytic subunit (1990), Proc. Natl. Acad. Sci. USA, 87, 7978-7982.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.64 rat (MPP1 polypeptide) Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.64 EDTA excess Mn2+ restores Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.64 mitochondrion
-
 Rattus norvegicus 5739
-
3.4.24.64 soluble
-
 Rattus norvegicus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.64 Mn2+ requirement Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.64 52000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus
3.4.24.64 55000
-
 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.64 additional information Rattus norvegicus removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes ?
-
 ?
3.4.24.64 additional information Rattus norvegicus polypeptides destined to be imported from cytosol into mitochondrial matrix or inner mitochondrial membrane, critical step in the import of nuclear encoded precursor proteins into mitochondria ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.64 More
-
 homology between rat, yeast and Neurospora enzymes
-
3.4.24.64 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.64 2 components, a catalytically active MW 55000 and a MW 52000 subunit in a 1:1 ratio Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.64 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.64 additional information removes amino-terminal matrix-targeting sequences from imported mitochondrial precursor proteins during or after translocation across mitochondrial membranes Rattus norvegicus ?
-
 ?
3.4.24.64 additional information polypeptides destined to be imported from cytosol into mitochondrial matrix or inner mitochondrial membrane, critical step in the import of nuclear encoded precursor proteins into mitochondria Rattus norvegicus ?
-
 ?
3.4.24.64 MPPI precursor + H2O MPPI presumably takes part in its own precursor activation Rattus norvegicus MPPI
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.64 dimer 1 * 52000 + 1 * 55000, SDS-PAGE Rattus norvegicus