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Literature summary extracted from

  • Plevrakis, I.; Clamagirand, C.; Creminon, C.; Brakch, N.; Rholam, M.; Cohen, P.
    Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor (1989), Biochemistry, 28, 2705-2710.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.62 EDTA peptide I as substrate; strong, 2.5 mM Bos taurus
3.4.24.62 EGTA peptide I as substrate; strong, 2.5 mM Bos taurus
3.4.24.62 additional information [D-Lys11]-pro-oxytocin/neurophysin(1-20), Gly-Gly-Lys-D-Arg-Ala-Val, Cys-Pro-Leu-Gly-Gly-Lys-D-Arg-Ala-Val; no inhibition by PMSF, pepstatin Bos taurus
3.4.24.62 p-chloromercuriphenylsulfonic acid 2.5 mM; peptide I as substrate Bos taurus
3.4.24.62 PCMB 2.5 mM; peptide I as substrate Bos taurus
3.4.24.62 [D-Arg12]-Pro-oxytocin/neurophysin(1-20) kinetics; peptide I as substrate Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.62 0.05
-
peptide I neurohypophyseal enzyme Bos taurus
3.4.24.62 0.2
-
peptide I corpus luteum Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.24.62 secretory granule
-
Bos taurus 30141
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.62 52000
-
bovine, PAGE, 2 isoforms, MW 52000 and 58000 Bos taurus
3.4.24.62 58000
-
bovine, PAGE, 2 isoforms, MW 52000 and 58000 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.62 Bos taurus
-
cow
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.62 affinity chromatography Bos taurus
3.4.24.62 from purified vesicles Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.62 corpus luteum
-
Bos taurus
-
3.4.24.62 hypophysis pituitary neurosecretory granule Bos taurus
-
3.4.24.62 neurohypophysis
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.62 peptide I + H2O
-
Bos taurus ?
-
?
3.4.24.62 Pro-oxytocin/neurophysin(1-20) + H2O i.e. model substrate peptide I Bos taurus Pro-oxytocin/neurophysin(1-12) + pro-oxytocin/neurophysin(13-20)
-
?

Subunits

EC Number Subunits Comment Organism
3.4.24.62 monomer 1 * 52000, SDS-PAGE, 1 * 58000, SDS-PAGE, 2 isoforms, MW 52000 and 58000 Bos taurus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.4.24.62 37
-
assay at Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.62 additional information
-
pI: 4.9 or 6.9 (corpus luteum, different enzyme preparations) Bos taurus
3.4.24.62 additional information
-
pI: 6.9 and 7.1 (2 isoforms) Bos taurus
3.4.24.62 7
-
around, peptide I as substrate Bos taurus