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Literature summary extracted from

  • Burghen, G.A.; Kitabchi, A.E.; Brush, J.S.
    Characterization of a rat liver protease with specificity for insulin (1972), Endocrinology, 91, 633-642.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.24.56 glutathione stimulates Rattus norvegicus
3.4.24.56 mercaptoethanol stimulates Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 NEM
-
 Rattus norvegicus
3.4.24.56 p-hydroxymercuribenzoate
-
 Rattus norvegicus
3.4.24.56 Phenformin
-
 Rattus norvegicus
3.4.24.56 Tolbutamide
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.24.56 0.0001
-
 Insulin
-
 Rattus norvegicus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.56 80000
-
 rat, gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Rattus norvegicus major route of insulin catabolism in body ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.56
-
 Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.56 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?
3.4.24.56 insulin + H2O major route of insulin catabolism in body Rattus norvegicus ?
-
 ?
3.4.24.56 additional information human growth hormone is not appreciably degraded Rattus norvegicus ?
-
 ?
3.4.24.56 Proinsulin + H2O 15fold greater rate of insulin destruction over that for proinsulin Rattus norvegicus Hydrolyzed proinsulin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.24.56 7.6
-
-
 Rattus norvegicus