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Literature summary extracted from

  • Becker, A.B.; Roth, R.A.
    Insulysin and pitrilysin: insulin-degrading enzymes of mammals and bacteria (1995), Methods Enzymol., 248, 693-703.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.24.56 Drosophila melanogaster Drosophila melanogaster
3.4.24.56 Drosophila melanogaster Homo sapiens
3.4.24.56 Eimeria bovis Drosophila melanogaster
3.4.24.56 Eimeria bovis Homo sapiens
3.4.24.56 human Drosophila melanogaster
3.4.24.56 human Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.56 sulfhydryl-modifying reagents Drosophila, human and rat enzyme inhibited, bacterial enzyme not Drosophila melanogaster
3.4.24.56 sulfhydryl-modifying reagents Drosophila, human and rat enzyme inhibited, bacterial enzyme not Homo sapiens
3.4.24.56 sulfhydryl-modifying reagents Drosophila, human and rat enzyme inhibited, bacterial enzyme not Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.24.56 insulin + H2O Drosophila melanogaster implicated in the process of membrane fusion and cell development ?
-
 ?
3.4.24.56 insulin + H2O Mammalia implicated in the process of membrane fusion and cell development ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens implicated in the process of membrane fusion and cell development ?
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus implicated in the process of membrane fusion and cell development ?
-
 ?
3.4.24.56 insulin + H2O Drosophila melanogaster insulin degradation ?
-
 ?
3.4.24.56 insulin + H2O Mammalia insulin degradation ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens insulin degradation ?
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus insulin degradation ?
-
 ?
3.4.24.56 insulin + H2O Drosophila melanogaster the enzyme may play a general role in hormone metabolism and cellular regulation ?
-
 ?
3.4.24.56 insulin + H2O Mammalia the enzyme may play a general role in hormone metabolism and cellular regulation ?
-
 ?
3.4.24.56 insulin + H2O Homo sapiens the enzyme may play a general role in hormone metabolism and cellular regulation ?
-
 ?
3.4.24.56 insulin + H2O Rattus norvegicus the enzyme may play a general role in hormone metabolism and cellular regulation ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.56 Drosophila melanogaster
-
-
-
3.4.24.56 Homo sapiens
-
-
-
3.4.24.56 Mammalia
-
-
-
3.4.24.56 Rattus norvegicus
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.4.24.56 additional information
-
 assay methods Drosophila melanogaster
3.4.24.56 additional information
-
 assay methods Mammalia
3.4.24.56 additional information
-
 assay methods Homo sapiens
3.4.24.56 additional information
-
 assay methods Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.56 Atrial natriuretic factor + H2O
-
 Drosophila melanogaster ?
-
 ?
3.4.24.56 Atrial natriuretic factor + H2O
-
 Mammalia ?
-
 ?
3.4.24.56 Atrial natriuretic factor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 Atrial natriuretic factor + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 Glucagon + H2O
-
 Drosophila melanogaster Hydrolyzed glucagon
-
 ?
3.4.24.56 Glucagon + H2O
-
 Mammalia Hydrolyzed glucagon
-
 ?
3.4.24.56 Glucagon + H2O
-
 Homo sapiens Hydrolyzed glucagon
-
 ?
3.4.24.56 Glucagon + H2O
-
 Rattus norvegicus Hydrolyzed glucagon
-
 ?
3.4.24.56 Insulin + H2O
-
 Drosophila melanogaster Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin + H2O
-
 Mammalia Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin + H2O
-
 Homo sapiens Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin + H2O
-
 Rattus norvegicus Hydrolyzed insulin
-
 ?
3.4.24.56 insulin + H2O implicated in the process of membrane fusion and cell development Drosophila melanogaster ?
-
 ?
3.4.24.56 insulin + H2O implicated in the process of membrane fusion and cell development Mammalia ?
-
 ?
3.4.24.56 insulin + H2O implicated in the process of membrane fusion and cell development Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O implicated in the process of membrane fusion and cell development Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O insulin degradation Drosophila melanogaster ?
-
 ?
3.4.24.56 insulin + H2O insulin degradation Mammalia ?
-
 ?
3.4.24.56 insulin + H2O insulin degradation Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O insulin degradation Rattus norvegicus ?
-
 ?
3.4.24.56 insulin + H2O the enzyme may play a general role in hormone metabolism and cellular regulation Drosophila melanogaster ?
-
 ?
3.4.24.56 insulin + H2O the enzyme may play a general role in hormone metabolism and cellular regulation Mammalia ?
-
 ?
3.4.24.56 insulin + H2O the enzyme may play a general role in hormone metabolism and cellular regulation Homo sapiens ?
-
 ?
3.4.24.56 insulin + H2O the enzyme may play a general role in hormone metabolism and cellular regulation Rattus norvegicus ?
-
 ?
3.4.24.56 Oxidatively damaged hemoglobin + H2O
-
 Drosophila melanogaster ?
-
 ?
3.4.24.56 Oxidatively damaged hemoglobin + H2O
-
 Mammalia ?
-
 ?
3.4.24.56 Oxidatively damaged hemoglobin + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 Oxidatively damaged hemoglobin + H2O
-
 Rattus norvegicus ?
-
 ?
3.4.24.56 Transforming growth factor + H2O
-
 Drosophila melanogaster ?
-
 ?
3.4.24.56 Transforming growth factor + H2O
-
 Mammalia ?
-
 ?
3.4.24.56 Transforming growth factor + H2O
-
 Homo sapiens ?
-
 ?
3.4.24.56 Transforming growth factor + H2O
-
 Rattus norvegicus ?
-
 ?