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Literature summary extracted from

  • Ding, L.; Becker, A.B.; Suzuki, A.; Roth, R.A.
    Comparison of the enzymatic and biochemical properties of human insulin-degrading enzyme and Escherichia coli protease III (1992), J. Biol. Chem., 267, 2414-2420.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.24.55 bacitracin
-
 Escherichia coli
3.4.24.55 Chelating agents
-
 Escherichia coli
3.4.24.56 1,10-phenanthroline
-
 Homo sapiens
3.4.24.56 bacitracin
-
 Homo sapiens
3.4.24.56 Chelating agents
-
 Homo sapiens
3.4.24.56 EDTA
-
 Homo sapiens
3.4.24.56 additional information not: phenylmethanesulfonyl fluoride; not: phosphoramidon Homo sapiens
3.4.24.56 NEM
-
 Homo sapiens
3.4.24.56 Sulfhydryl-alkylating agents
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.55 Zn2+ contains 0.6 mol of zinc per mol of enzyme Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.55 Escherichia coli
-
-
-
3.4.24.56 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.24.56 partial Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.24.55 Insulin + H2O degradation in such a way that its receptor binding activity is rapidly lost but its precipitability in trichloroacetic acid is only slightly decreased Escherichia coli Hydrolyzed insulin
-
 ?
3.4.24.55 Insulin-like growth factor II + H2O
-
 Escherichia coli ?
-
 ?
3.4.24.56 Insulin + H2O much better degradation than insulin growth factor II Homo sapiens Hydrolyzed insulin
-
 ?
3.4.24.56 Insulin growth factor II + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.24.56 More human enzyme partially exists as homodimer or heterodimer Homo sapiens