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Literature summary extracted from

  • McNamara, D.B.; Hussey, J.L.; Kerstein, M.D.; Rosenson, R.S.; Hyman, A.L.; Kadowitz, P.J.
    Modulation of prostacyclin synthetase and unmasking of PGE2 isomerase in bovine coronary arterial microsomes (1984), Biochem. Biophys. Res. Commun., 118, 33-39.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.3 dithiothreitol activates Homo sapiens
5.3.99.3 dithiothreitol activates Bos taurus
5.3.99.3 dithiothreitol activates Ovis aries
5.3.99.3 dithiothreitol activates Canis lupus familiaris
5.3.99.3 GSH activates Homo sapiens
5.3.99.3 GSH activates Bos taurus
5.3.99.3 GSH activates Ovis aries
5.3.99.3 GSH activates Canis lupus familiaris
5.3.99.4 dithiothreitol increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM Bos taurus
5.3.99.4 reduced glutathione increase in activity with increasing glutathione concentration from 0.1 mM up to 5 mM Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.99.4 tranylcypromine 10 mM, 90% inhibition in absence or presence of 2 mM reduced glutathione Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 microsome
-
Bos taurus
-
-
5.3.99.3 microsome
-
Ovis aries
-
-
5.3.99.4 microsome
-
Bos taurus
-
-
5.3.99.4 microsome
-
Ovis aries
-
-

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Bos taurus
-
-
-
5.3.99.3 Canis lupus familiaris
-
-
-
5.3.99.3 Homo sapiens
-
-
-
5.3.99.3 Ovis aries
-
-
-
5.3.99.4 Bos taurus
-
-
-
5.3.99.4 Canis lupus familiaris
-
-
-
5.3.99.4 Homo sapiens
-
-
-
5.3.99.4 Ovis aries
-
ram
-

Oxidation Stability

EC Number Oxidation Stability Organism
5.3.99.4 the prostacyclin synthase is unusually sensitive to the redox state or sulfhydryl oxidation of the enzyme Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 coronary artery
-
Bos taurus
-
5.3.99.4 coronary artery
-
Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 Prostaglandin H2 i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid Bos taurus Prostaglandin E2
-
?
5.3.99.3 Prostaglandin H2 i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid Ovis aries Prostaglandin E2
-
?
5.3.99.4 Prostaglandin H2
-
Homo sapiens Prostaglandin I2 prostaglandin I2 ?
5.3.99.4 Prostaglandin H2
-
Bos taurus Prostaglandin I2 prostaglandin I2 ?
5.3.99.4 Prostaglandin H2
-
Ovis aries Prostaglandin I2 prostaglandin I2 ?
5.3.99.4 Prostaglandin H2
-
Canis lupus familiaris Prostaglandin I2 prostaglandin I2 ?