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Literature summary extracted from
- Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e (1978), Biochemistry, 17, 3395-3404.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.41 | 1,10-phenanthroline | - |
Crotalus atrox |  |
| 3.4.24.41 | EDTA | - |
Crotalus atrox | |
| 3.4.24.42 | 1,10-phenanthroline | - |
Crotalus atrox | |
| 3.4.24.42 | EDTA | - |
Crotalus atrox | |
| 3.4.24.44 | 1,10-phenanthroline | - |
Crotalus atrox | |
| 3.4.24.44 | EDTA | Zn2+ restores | Crotalus atrox | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.24.41 | Zn2+ | 0.82 mol zinc/mol enzyme | Crotalus atrox | |
| 3.4.24.42 | Zn2+ | zinc metalloproteinase | Crotalus atrox | |
| 3.4.24.42 | Zn2+ | 0.86 mol zinc/mol enzyme | Crotalus atrox | |
| 3.4.24.44 | additional information | metal analysis detects 0.42 mol Ca2+ and 0.05 mol Mg2+ per mol enzyme | Crotalus atrox | |
| 3.4.24.44 | Zn2+ | zinc metalloproteinase | Crotalus atrox | |
| 3.4.24.44 | Zn2+ | 1 mol zinc/mol enzyme | Crotalus atrox | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.24.41 | 19000 | - |
Crotalus atrox, gel filtration | Crotalus atrox |
| 3.4.24.41 | 24000 | - |
1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
| 3.4.24.41 | 29300 | - |
Crotalus atrox, minimal MW calculated from zinc content | Crotalus atrox |
| 3.4.24.42 | additional information | - |
amino acid composition | Crotalus atrox |
| 3.4.24.42 | 20500 | - |
Crotalus atrox, isozyme Ht-c, gel filtration | Crotalus atrox |
| 3.4.24.42 | 21000 | - |
Crotalus atrox, isozyme Ht-d, gel filtration | Crotalus atrox |
| 3.4.24.42 | 27900 | - |
Crotalus atrox, minimal MW calculated from zinc content | Crotalus atrox |
| 3.4.24.44 | 22000 | - |
Crotalus atrox, gel filtration | Crotalus atrox |
| 3.4.24.44 | 25000 | - |
Crotalus atrox, minimum MW calculated from zinc content | Crotalus atrox |
| 3.4.24.44 | 25700 | - |
1 * 25700, Crotalus atrox, SDS-PAGE | Crotalus atrox |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.42 | Basement membranes surrounding capillaries + H2O | Crotalus atrox | together with hemorrhagic toxins a, b, e and f responsible for hemorrhage | ? | - |
? | |
| 3.4.24.42 | Basement membranes surrounding capillaries + H2O | Crotalus atrox | less potent hemorrhagic toxins of Crotalus atrox venom | ? | - |
? | |
| 3.4.24.44 | Basement membranes surrounding capillaries + H2O | Crotalus atrox | together with hemorrhagic toxins a, b, c, d and f responsible for hemorrhage | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.24.41 | Crotalus atrox | - |
Western diamondback rattlesnake | - |
| 3.4.24.42 | Crotalus atrox | - |
Western diamondback rattlesnake | - |
| 3.4.24.44 | Crotalus atrox | - |
Western diamondback rattlesnake | - |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 3.4.24.44 | additional information | no glycoprotein | Crotalus atrox |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.24.41 | from lyophilized crude venom | Crotalus atrox |
| 3.4.24.42 | from lyophilized crude venom | Crotalus atrox |
| 3.4.24.44 | from lyophilized crude venom | Crotalus atrox |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.24.41 | venom | - |
Crotalus atrox | - |
| 3.4.24.42 | venom | - |
Crotalus atrox | - |
| 3.4.24.44 | venom | - |
Crotalus atrox | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.24.41 | Dimethylcasein + H2O | - |
Crotalus atrox | ? | - |
? | |
| 3.4.24.42 | Basement membranes surrounding capillaries + H2O | together with hemorrhagic toxins a, b, e and f responsible for hemorrhage | Crotalus atrox | ? | - |
? | |
| 3.4.24.42 | Basement membranes surrounding capillaries + H2O | less potent hemorrhagic toxins of Crotalus atrox venom | Crotalus atrox | ? | - |
? | |
| 3.4.24.44 | Basement membranes surrounding capillaries + H2O | together with hemorrhagic toxins a, b, c, d and f responsible for hemorrhage | Crotalus atrox | ? | - |
? | |
| 3.4.24.44 | Dimethylcasein + H2O | - |
Crotalus atrox | ? | - |
? | |
| 3.4.24.44 | Dimethylhemoglobin + H2O | - |
Crotalus atrox | ? | - |
? | |
| 3.4.24.44 | additional information | no hydrolysis of furylacryloyl-L-leucinamide | Crotalus atrox | ? | - |
? | |
| 3.4.24.44 | additional information | no hydrolysis of native collagens | Crotalus atrox | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.24.41 | monomer | 1 * 24000, Crotalus atrox, SDS-PAGE | Crotalus atrox |
| 3.4.24.44 | monomer | 1 * 25700, Crotalus atrox, SDS-PAGE | Crotalus atrox |
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