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Literature summary extracted from
- Immunochemical and kinetic evidence for two different prostaglandin H-prostaglandin E isomerases in sheep vesicular gland microsomes (1987), J. Biol. Chem., 262, 1374-1381.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | GSH | dependent on | Ovis aries |  |
| 5.3.99.3 | GSH | concentrations below 0.5 mM are required for maximal activity of IgG1(hei-26)-reactive protein | Ovis aries | |
| 5.3.99.3 | GSH | 2 mM required for maximal activity of IgG1(hei-7)-reactive protein | Ovis aries | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.3 | 0.04 | - |
prostaglandin H2 | IgG1(hei-7)-reactive protein | Ovis aries | |
| 5.3.99.3 | 0.15 | - |
prostaglandin H2 | IgG1(hei-26)-reactive protein | Ovis aries | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 5.3.99.3 | microsome | at least 2 different proteins with PGE-PGH isomerase activity | Ovis aries | - |
- |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.3 | 17500 | - |
x * 17500, IgG1(hei-7)-reactive protein, SDS-PAGE | Ovis aries |
| 5.3.99.3 | 180000 | - |
x * 180000, IgG1(hei-26)-reactive protein, SDS-PAGE | Ovis aries |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | Ovis aries | - |
at least 2 different proteins with PGE-PGH isomerase activity: IgG1(hei-7)-reactive protein and IgG1(hei-26)-reactive protein | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.99.3 | - |
Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | epithelium | at least 2 different proteins with PGE-PGH isomerase activity | Ovis aries | - |
| 5.3.99.3 | epithelium | epithelium cells | Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | Prostaglandin H2 | i.e. 15-hydroxy-9alpha,11alpha-peroxidoprosta-5,13-dienoic acid | Ovis aries | Prostaglandin E2 | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | ? | x * 17500, IgG1(hei-7)-reactive protein, SDS-PAGE | Ovis aries |
| 5.3.99.3 | ? | x * 180000, IgG1(hei-26)-reactive protein, SDS-PAGE | Ovis aries |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 5.3.99.3 | 6.2 | - |
IgG1(hei-26)-reactive protein | Ovis aries |
| 5.3.99.3 | 6.5 | 7.5 | IgG1(hei-7)-reactive protein | Ovis aries |
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