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Literature summary extracted from

  • Bode, W.; Gomis-Ruth, F.X.; Stöckler, W.
    Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the metzincins (1993), FEBS Lett., 331, 134-140.
    View publication on PubMed

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
3.4.24.21 astacin structure compared to those of thermolysin and adamalysin II Astacus astacus
3.4.24.21 Astacus astacus Astacus astacus
3.4.24.40 Pseudomonas aeruginosa Pseudomonas aeruginosa
3.4.24.46 Crotalus adamanteus Crotalus adamanteus
3.4.24.46 structure Crotalus adamanteus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.4.24.21 Zn2+ requirement Astacus astacus
3.4.24.21 Zn2+ zinc metalloenzyme Astacus astacus
3.4.24.40 Zn2+ zinc-binding consensus sequence in comparison to astacins, snake venom, matrix metalloproteinases Pseudomonas aeruginosa
3.4.24.40 Zn2+ zinc-binding consensus sequence in comparison to astacins, snake venom, matrix metalloproteinases Serratia marcescens
3.4.24.40 Zn2+ zinc-binding consensus sequence in comparison to astacins, snake venom, matrix metalloproteinases Dickeya chrysanthemi
3.4.24.40 Zn2+ zinc-containing metalloproteinase Pseudomonas aeruginosa
3.4.24.40 Zn2+ zinc-containing metalloproteinase Serratia marcescens
3.4.24.40 Zn2+ zinc-containing metalloproteinase Dickeya chrysanthemi
3.4.24.46 Zn2+ zinc containing metalloproteinase Crotalus adamanteus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.24.40 additional information
-
 amino acid sequence alignment Pseudomonas aeruginosa
3.4.24.40 additional information
-
 amino acid sequence alignment Serratia marcescens
3.4.24.40 additional information
-
 amino acid sequence alignment Dickeya chrysanthemi

Organism

EC Number Organism UniProt Comment Textmining
3.4.24.21 Astacus astacus
-
-
-
3.4.24.40 Dickeya chrysanthemi
-
 plant pathogen
-
3.4.24.40 Pseudomonas aeruginosa
-
-
-
3.4.24.40 Serratia marcescens
-
-
-
3.4.24.46 Crotalus adamanteus
-
 Eastern diamondback rattlesnake
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.24.46 venom
-
 Crotalus adamanteus
-

Synonyms

EC Number Synonyms Comment Organism
3.4.24.40 More subfamily serralysins together with astacins, snake venom and matrix metalloproteinases should be grouped into a common family, the metzincins (closely related to the thermolysin family) Pseudomonas aeruginosa
3.4.24.40 More subfamily serralysins together with astacins, snake venom and matrix metalloproteinases should be grouped into a common family, the metzincins (closely related to the thermolysin family) Serratia marcescens
3.4.24.40 More subfamily serralysins together with astacins, snake venom and matrix metalloproteinases should be grouped into a common family, the metzincins (closely related to the thermolysin family) Dickeya chrysanthemi