Any feedback?
Literature summary extracted from
- Protein disulfide isomerase (1998), Methods Enzymol., 290, 26-50.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | expression in Escherichia coli | Rattus norvegicus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 5.3.4.1 | 0.005 | - |
insulin-(SS) | - |
Rattus norvegicus | |
| 5.3.4.1 | 17 | - |
GSH | - |
Rattus norvegicus |  |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 5.3.4.1 | 55114 | - |
x * 55114, calculation from nucleotide sequence | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | additional information | Bos taurus | - |
? | - |
? | |
| 5.3.4.1 | additional information | Mammalia | protein disulfide isomerase serves as a subunit of at least two enzymes, the beta-subunit of the enzyme prolyl hydroxylase and an ER triglyceride transferase | ? | - |
? | |
| 5.3.4.1 | Proteins | Rattus norvegicus | - |
? | - |
? | |
| 5.3.4.1 | Proteins | Bos taurus | - |
? | - |
? | |
| 5.3.4.1 | Proteins | Mammalia | when present in large stoichiometric excess relative to an unfolded protein substrate, the enzyme can exhibit chaperone activity, inhibiting aggregation and increasing the recovery of native protein | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.4.1 | Bos taurus | - |
- |
- |
| 5.3.4.1 | Mammalia | - |
- |
- |
| 5.3.4.1 | Rattus norvegicus | - |
- |
- |
| 5.3.4.1 | Saccharomyces cerevisiae | - |
- |
- |
Posttranslational Modification
| EC Number | Posttranslational Modification | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | glycoprotein | - |
Saccharomyces cerevisiae |
| 5.3.4.1 | glycoprotein | - |
Bos taurus |
| 5.3.4.1 | no glycoprotein | - |
Rattus norvegicus |
| 5.3.4.1 | no glycoprotein | - |
Bos taurus |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 5.3.4.1 | - |
Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.4.1 | Insulin-(SS) + GSH | - |
Rattus norvegicus | Insulin-(SH)2 + GSSG | - |
? | |
| 5.3.4.1 | Insulin-(SS) + GSH | - |
Bos taurus | Insulin-(SH)2 + GSSG | - |
? | |
| 5.3.4.1 | additional information | - |
Bos taurus | ? | - |
? | |
| 5.3.4.1 | additional information | protein disulfide isomerase serves as a subunit of at least two enzymes, the beta-subunit of the enzyme prolyl hydroxylase and an ER triglyceride transferase | Mammalia | ? | - |
? | |
| 5.3.4.1 | Proteins | native, reduced or with wrong disulfide bonds | Mammalia | Proteins | with correct disulfide bonds | ? | |
| 5.3.4.1 | Proteins | native, reduced or with wrong disulfide bonds | Rattus norvegicus | Proteins | with correct disulfide bonds | ? | |
| 5.3.4.1 | Proteins | native, reduced or with wrong disulfide bonds | Saccharomyces cerevisiae | Proteins | with correct disulfide bonds | ? | |
| 5.3.4.1 | Proteins | native, reduced or with wrong disulfide bonds | Bos taurus | Proteins | with correct disulfide bonds | ? | |
| 5.3.4.1 | Proteins | incorrectly disulfide-linked RNAse | Rattus norvegicus | Proteins | with correct disulfide bonds | ? | |
| 5.3.4.1 | Proteins | - |
Rattus norvegicus | ? | - |
? | |
| 5.3.4.1 | Proteins | - |
Bos taurus | ? | - |
? | |
| 5.3.4.1 | Proteins | when present in large stoichiometric excess relative to an unfolded protein substrate, the enzyme can exhibit chaperone activity, inhibiting aggregation and increasing the recovery of native protein | Mammalia | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 5.3.4.1 | ? | - |
Bos taurus |
| 5.3.4.1 | ? | x * 55114, calculation from nucleotide sequence | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
