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Literature summary extracted from

  • Sternberg, M.
    Bond specificity, active site and milk clotting mechanism of the Mucor miehei protease (1972), Biochim. Biophys. Acta, 285, 383-392.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.23 2,4-Dinitro-1-fluorobenzene
-
 Rhizomucor miehei
3.4.23.23 Diazoacetyl-glycyl ethyl ester in presence of copper ions Rhizomucor miehei

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.23 Rhizomucor miehei
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.23 Benzyloxycarbonyl-Gly-Phe-Phe + H2O
-
 Rhizomucor miehei ?
-
 ?
3.4.23.23 Benzyloxycarbonyl-Phe-Tyr + H2O
-
 Rhizomucor miehei ?
-
 ?
3.4.23.23 additional information milk clotting activity Rhizomucor miehei ?
-
 ?
3.4.23.23 additional information specificity against aromatic bulky or hydrophobic amino acid residues at both sides of the splitting point Rhizomucor miehei ?
-
 ?
3.4.23.23 Oxidized insulin B-chain + H2O hydrolysis at: Phe1-Val2, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Phe24-Phe25, Phe25-Tyr26, Tyr26-Thr27 Rhizomucor miehei Hydrolyzed oxidized B-chain of insulin
-
 ?
3.4.23.23 Peptides + H2O carbobenzoxy-Phe-Met methyl ester containing the bond involved in milk clotting mechanism is not hydrolyzed unless it becomes part of a polypeptide with tails of carbobenzoxy-Phe-Met anchored on a polylysine chain Rhizomucor miehei Hydrolyzed peptides
-
 ?
3.4.23.23 Proteins + H2O preferentially hydrolyzes peptide bonds having an aromatic amino acid as carboxyl donor Rhizomucor miehei Hydrolyzed proteins
-
 ?
3.4.23.23 Proteins + H2O involving aromatic residues Rhizomucor miehei Hydrolyzed proteins
-
 ?
3.4.23.23 Val-Tyr-Val + H2O
-
 Rhizomucor miehei ?
-
 ?