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Literature summary extracted from
- The structure and function of acid proteases. VI. Effects of acid protease-specific inhibitors on the acid proteases from Aspergillus niger var. macrosporus (1976), J. Biochem., 80, 975-981.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.23.18 | 1,2-epoxy-3-(4-nitrophenoxy)propane | the reaction is markedly inhibited by pepstatin | Aspergillus niger |  |
| 3.4.23.18 | Diazoacetyl-DL-norleucine methyl ester | in the presence of Cu2+; pH-profile; the reaction is markedly inhibited by pepstatin | Aspergillus niger | |
| 3.4.23.18 | DL-1-Diazo-3-tosylamido-2-heptanone | in the presence of Cu2+ | Aspergillus niger | |
| 3.4.23.18 | L-1-Diazo-3-tosylamido-4-phenyl-2-butanone | in the presence of Cu2+ | Aspergillus niger | |
| 3.4.23.18 | pepstatin | - |
Aspergillus niger | |
| 3.4.23.19 | 1,2-epoxy-3-(4-nitrophenoxy)propane | pH-profile | Aspergillus niger | |
| 3.4.23.19 | Diazoacetyl-DL-norleucine methyl ester | in the presence of Cu2+; pH-profile | Aspergillus niger | |
| 3.4.23.19 | DL-1-Diazo-3-tosylamido-2-heptanone | - |
Aspergillus niger | |
| 3.4.23.19 | L-1-Diazo-3-tosylamido-4-phenyl-2-butanone | - |
Aspergillus niger | |
| 3.4.23.19 | additional information | no inhibition by pepstatin | Aspergillus niger |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 3.4.23.19 | extracellular | - |
Aspergillus niger | - |
- |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.23.18 | Aspergillus niger | - |
var. macrosporus | - |
| 3.4.23.19 | Aspergillus niger | - |
var. macrosporus | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.23.19 | culture filtrate | - |
Aspergillus niger | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.23.19 | Hemoglobin + H2O | acid denatured hemoglobin | Aspergillus niger | Hydrolyzed hemoglobin | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 3.4.23.19 | More | belongs to different class than EC 3.4.23.18 | Aspergillus niger |
| 3.4.23.19 | More | non-pepsin-type acid proteinase | Aspergillus niger |
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