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Literature summary extracted from

  • Takahashi, K.; Chang, W.J.
    The structure and function of acid proteases. V. Comparative studies on the specific inhibition of acid proteases by diazoacetyl-DL-norleucine methyl ester, 1,2-epoxy-3-(p-nitrophenoxy) propane and pepstatin (1976), J. Biochem., 80, 497-506.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.18 Diazoacetyl-DL-norleucine methyl ester in the presence of Cu2+; pH-profile Aspergillus niger
3.4.23.18 Diazoacetyl-DL-norleucine methyl ester in the presence of Cu2+; pH-profile Aspergillus phoenicis
3.4.23.18 pepstatin kinetics Aspergillus niger
3.4.23.18 pepstatin kinetics Aspergillus phoenicis
3.4.23.21 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Rhizopus microsporus var. chinensis
3.4.23.21 Diazoacetyl-DL-norleucine methyl ester Cu2+ essential for this reaction Rhizopus microsporus var. chinensis
3.4.23.21 pepstatin
-
Rhizopus microsporus var. chinensis
3.4.23.23 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Rhizomucor pusillus
3.4.23.23 Diazoacetyl-DL-norleucine methyl ester
-
Rhizomucor pusillus
3.4.23.23 pepstatin
-
Rhizomucor pusillus
3.4.23.26 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Paecilomyces variotii
3.4.23.26 Diazoacetyl-DL-norleucine methyl ester in presence of Cu2+; pH optimum of inactivation: 5.5-6 Paecilomyces variotii
3.4.23.26 pepstatin
-
Paecilomyces variotii
3.4.23.28 1,2-epoxy-3-(4-nitrophenoxy)propane
-
Acrocylindrium sp.
3.4.23.28 Diazoacetyl-DL-norleucine methyl ester
-
Acrocylindrium sp.
3.4.23.28 pepstatin
-
Acrocylindrium sp.

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.18 Aspergillus niger
-
var. macrosporus
-
3.4.23.18 Aspergillus phoenicis
-
-
-
3.4.23.21 Rhizopus microsporus var. chinensis
-
-
-
3.4.23.23 Rhizomucor pusillus
-
-
-
3.4.23.26 Paecilomyces variotii
-
-
-
3.4.23.28 Acrocylindrium sp.
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.18 Hemoglobin + H2O
-
Aspergillus niger ?
-
?
3.4.23.18 Hemoglobin + H2O
-
Aspergillus phoenicis ?
-
?