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Literature summary extracted from

  • Parish, D.C.; Tuteja, R.; Altstein, M.; Gainer, H.; Loh, Y.P.
    Purification and characterization of a paired basic residue-specific prohormone-converting enzyme from bovine pituitary neural lobe secretory vesicles (1986), J. Biol. Chem., 261, 14392-14397.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.23.17 leupeptin
-
 Bos taurus
3.4.23.17 pepstatin A
-
 Bos taurus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.23.17 70000
-
 x * 70000, bovine Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
3.4.23.17 Bos taurus
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.4.23.17 glycoprotein
-
 Bos taurus

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.23.17
-
 Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.23.17 hypophysis neural Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.23.17 Pro-insulin + H2O
-
 Bos taurus Insulin A-chain + insulin B-chain
-
 ?
3.4.23.17 Pro-opiomelanocortin + H2O
-
 Bos taurus Adrenocorticotropin + beta-lipotropin
-
 ?
3.4.23.17 Provasopressin + H2O cleavage occurs primarily on the carboxyl side of the arginine in the pair of Lys-Arg basic residues separating the vasopressin peptide from the neurophysin moiety in the precursor Bos taurus Arginine vasopressin-Gly10-Lys11-Arg12 major product ?
3.4.23.17 Provasopressin + H2O human vasopressin prohormone Bos taurus Arginine vasopressin-Gly10-Lys11-Arg12 major product ?

Subunits

EC Number Subunits Comment Organism
3.4.23.17 ? SDS-PAGE Bos taurus
3.4.23.17 ? x * 70000, bovine Bos taurus