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Literature summary extracted from

  • Kamiya, T.; Kobayashi, Y.; Kanaoka, K.; Nakashima, T.; Kato, Y.; Mizuno, A.; Sakai, H.
    Fluorescence microscopic demonstration of cathepsin K activity a the major lysosomal cystein proteinase in osteoclasts (1998), J. Biochem., 123, 752-759.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 leupeptin
-
 Mus musculus
3.4.22.38 leupeptin
-
 Oryctolagus cuniculus
3.4.22.38 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane
-
 Mus musculus
3.4.22.38 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Oryctolagus cuniculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.22.38 cytoplasm
-
 Mus musculus 5737
-
3.4.22.38 cytoplasm
-
 Oryctolagus cuniculus 5737
-
3.4.22.38 lysosome
-
 Mus musculus 5764
-
3.4.22.38 lysosome
-
 Oryctolagus cuniculus 5764
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Mus musculus
-
-
-
3.4.22.38 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 additional information not in peritoneal macrophages Mus musculus
-
3.4.22.38 additional information not in peritoneal macrophages Oryctolagus cuniculus
-
3.4.22.38 osteoclast
-
 Mus musculus
-
3.4.22.38 osteoclast
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 Benzyloxycarbonyl-Leu-Arg 4-methoxy-2-naphthylamide + H2O
-
 Mus musculus Benzyloxycarbonyl-Leu-Arg + 4-methoxy-2-naphthylamine
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Arg 4-methoxy-2-naphthylamide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Leu-Arg + 4-methoxy-2-naphthylamine
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Mus musculus Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.38 5 6
-
 Mus musculus
3.4.22.38 5 6
-
 Oryctolagus cuniculus