Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Aibe, K.; Yazawa, H.; Abe, K.; Teramura, K.; Kumegawa, M.; Kawashima, H.; Honda, K.
    Substrate specificity of recombinant osteoclast cathepsin K from rabbits (1996), Biol. Pharm. Bull., 19, 1026-1031.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.38 expression in Escherichia coli Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.38 leupeptin
-
 Oryctolagus cuniculus
3.4.22.38 additional information not inhibitory are phenylmethylsulfonylfluoride, disopropyfluorophosohate, soybean inhibitor, pepstatin A Oryctolagus cuniculus
3.4.22.38 N-Acetyl-Leu-Leu-methional
-
 Oryctolagus cuniculus
3.4.22.38 trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane i.e. E-64 Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.4.22.38 0.013
-
 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide tert-butyloxycarbonyl-Ala-Gly-Pro- Arg 4-methylcoumarin 7-amide Oryctolagus cuniculus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.4.22.38 37000
-
 unglycosylated procathepsin K, gel filtration Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
3.4.22.38 Oryctolagus cuniculus
-
-
-

Renatured (Commentary)

EC Number Renatured (Comment) Organism
3.4.22.38 otimal pH for renaturation is 9.8, renaturation in the range 7.5-12 Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.22.38 osteoclast
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.22.38 Benzyloxycarbonyl-Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Leu-Leu-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Leu-Leu-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Benzyloxycarbonyl-Phe-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Benzyloxycarbonyl-Phe-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 D-Phe-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus D-Phe-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus Pro-Phe-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 tert-Butyloxycarbonyl-Ala-Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Ala-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 tert-Butyloxycarbonyl-Phe-Val-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
 ?
3.4.22.38 tert-Butyloxycarbonyl-Val-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Oryctolagus cuniculus tert-Butyloxycarbonyl-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.22.38 5.5
-
-
 Oryctolagus cuniculus

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.4.22.38 4 7.5
-
 Oryctolagus cuniculus