Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Polet, H.; Levine, L.
    Metabolism of prostaglandins E, A, and C in serum (1975), J. Biol. Chem., 250, 351-357.
    View publication on PubMed

General Stability

EC Number General Stability Organism
5.3.3.9 10% loss of activity after dialysis Homo sapiens
5.3.3.9 10% loss of activity after dialysis Oryctolagus cuniculus
5.3.3.9 loss of activity after pepsin digestion Homo sapiens
5.3.3.9 loss of activity after pepsin digestion Rattus norvegicus
5.3.3.9 loss of activity after pepsin digestion Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.3.3.9 5,5'-dithiobis(2-nitrobenzoate)
-
 Homo sapiens
5.3.3.9 5,5'-dithiobis(2-nitrobenzoate)
-
 Oryctolagus cuniculus
5.3.3.9 5,5'-dithiobis(2-nitrobenzoate)
-
 Rattus norvegicus
5.3.3.9 iodoacetate
-
 Homo sapiens
5.3.3.9 iodoacetate
-
 Oryctolagus cuniculus
5.3.3.9 NEM
-
 Homo sapiens
5.3.3.9 NEM
-
 Oryctolagus cuniculus
5.3.3.9 NEM
-
 Rattus norvegicus
5.3.3.9 p-mercuribenzoate
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
5.3.3.9 Canis lupus familiaris
-
-
-
5.3.3.9 Cavia porcellus
-
-
-
5.3.3.9 Felis catus
-
-
-
5.3.3.9 Homo sapiens
-
-
-
5.3.3.9 Mus musculus
-
-
-
5.3.3.9 no activity in Bos taurus
-
 ox
-
5.3.3.9 no activity in Gallus gallus
-
-
-
5.3.3.9 Oryctolagus cuniculus
-
-
-
5.3.3.9 Ovis aries
-
-
-
5.3.3.9 Rattus norvegicus
-
-
-
5.3.3.9 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.3.9 serum
-
 Mus musculus
-
5.3.3.9 serum
-
 Homo sapiens
-
5.3.3.9 serum
-
 Rattus norvegicus
-
5.3.3.9 serum
-
 Oryctolagus cuniculus
-
5.3.3.9 serum
-
 Felis catus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Cavia porcellus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Mus musculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Rattus norvegicus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Sus scrofa (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Ovis aries (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Canis lupus familiaris (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid
-
 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Homo sapiens (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Oryctolagus cuniculus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?
5.3.3.9 (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid i.e. prostaglandin A1 Felis catus (13E)-(15S)-15-Hydroxy-9-oxoprosta-8[12]13-dien-1-oic acid the product is prostaglandin C1, which is unstable under mild alkaline conditions and isomerizes to prostaglandin B1 ?

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
5.3.3.9 70
-
-
 Rattus norvegicus
5.3.3.9 70
-
-
 Felis catus
5.3.3.9 70
-
 20 min, 50-75% loss of activity Oryctolagus cuniculus
5.3.3.9 70
-
 20 min, 93% loss of activity Homo sapiens