Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Simon, M.M.; Kramer, M.D.
    Granzyme A (1994), Methods Enzymol., 244, 68-79.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.78
-
 Mus musculus
3.4.21.78
-
 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.78 Alpha1-proteinase inhibitor
-
 Homo sapiens
3.4.21.78 alpha2-Macroglobulin
-
 Homo sapiens
3.4.21.78 alpha2-Macroglobulin
-
 Mus musculus
3.4.21.78 antithrombin III
-
 Homo sapiens
3.4.21.78 antithrombin III
-
 Mus musculus
3.4.21.78 Aprotinin
-
 Homo sapiens
3.4.21.78 Aprotinin
-
 Mus musculus
3.4.21.78 benzamidine
-
 Homo sapiens
3.4.21.78 benzamidine
-
 Mus musculus
3.4.21.78 C1 esterase inhibitor
-
 Mus musculus
3.4.21.78 D-Pro-Phe-Arg-CH2Cl
-
 Mus musculus
3.4.21.78 diisopropyl fluorophosphate
-
 Homo sapiens
3.4.21.78 diisopropyl fluorophosphate
-
 Mus musculus
3.4.21.78 leupeptin
-
 Homo sapiens
3.4.21.78 leupeptin
-
 Mus musculus
3.4.21.78 phenylmethanesulfonyl fluoride
-
 Homo sapiens
3.4.21.78 phenylmethanesulfonyl fluoride
-
 Mus musculus
3.4.21.78 Protease nexin-1
-
 Mus musculus
3.4.21.78 Soybean trypsin inhibitor
-
 Homo sapiens
3.4.21.78 Soybean trypsin inhibitor
-
 Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.78 cytoplasm of effector cells Mus musculus 5737
-
3.4.21.78 cytoplasm of effector cells Homo sapiens 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.78 additional information Mus musculus overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection ?
-
 ?
3.4.21.78 additional information Homo sapiens overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.78 Homo sapiens
-
-
-
3.4.21.78 Mus musculus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.4.21.78
-
 Mus musculus
3.4.21.78
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.78 additional information enriched cytoplasmic granules Mus musculus
-
3.4.21.78 additional information enriched cytoplasmic granules Homo sapiens
-
3.4.21.78 T-lymphocyte cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes Mus musculus
-
3.4.21.78 T-lymphocyte cee lysates, activated, including normal peripheral blood lymphocytes previously sensitized by interleukin 2 or nitrogen, not expressed by resting T-lymphocytes Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.78 benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
 Mus musculus benzyloxycarbonyl-Lys + phenylmethanethiol
-
 ?
3.4.21.78 benzyloxycarbonyl-Lys-thiobenzyl ester + H2O
-
 Homo sapiens benzyloxycarbonyl-Lys + phenylmethanethiol
-
 ?
3.4.21.78 D-Pro-Phe-Arg 4-nitroanilide + H2O
-
 Mus musculus D-Pro-Phe-Arg + 4-nitroaniline
-
 ?
3.4.21.78 Gly-Pro-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.78 additional information overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection Mus musculus ?
-
 ?
3.4.21.78 additional information overview: possible roles of granzyme A: 1. involvement in T or NK cell-mediated cytolysis, 2. in extravasation of T-lymphocytes, 3. in regulation of B cell growth, 4. in control of viral infection Homo sapiens ?
-
 ?
3.4.21.78 Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Mus musculus ?
-
 ?
3.4.21.78 Pro-Phe-Arg 4-methylcoumarin 7-amide + H2O
-
 Homo sapiens ?
-
 ?
3.4.21.78 Tosyl-Gly-Pro-Arg 4-nitroanilide + H2O
-
 Homo sapiens ?
-
 ?

Subunits

EC Number Subunits Comment Organism
3.4.21.78 dimer enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively Mus musculus
3.4.21.78 dimer enzyme occurs as disulfide-linked homodimer of 60000 (mouse) and 50000 (human) with 2 catalytic sites, under reducing condition the MWs shift to 35000 and 25000, respectively Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.4.21.78 7.5 8.5 D-Pro-Phe-Arg 4-nitroanilide, mouse enzyme Mus musculus
3.4.21.78 8
-
 Gly-Pro-Arg 4-methylcoumarin 7-amide, human enzyme Homo sapiens
3.4.21.78 11
-
 tosyl-Gly-Pro-Arg 4-nitroanilide, human enzyme Homo sapiens