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Literature summary extracted from
- Substrate and inhibitor studies on proteinase 3 (1992), FEBS Lett., 297, 119-123.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.76 | 3,4-dichloroisocoumarin | - |
Homo sapiens |  |
| 3.4.21.76 | 7-Amino-4-chloro-3-(2-bromoethoxy)isocoumarin | - |
Homo sapiens | |
| 3.4.21.76 | additional information | substituted isocoumarins, peptide-phosphonates and chloromethyl ketones inhibit proteinase 3 less potently than human neutrophil elastase, by 1-2 orders of magnitude | Homo sapiens | |
| 3.4.21.76 | Substituted isocoumarins | - |
Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.76 | 0.028 | - |
tert-butyloxycarbonyl-Ala-Ala-Val-thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 0.031 | - |
tert-butyloxycarbonyl-Ala-Ala-Ile-thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 0.061 | - |
tert-butyloxycarbonyl-Ala-Ala-Met-thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 0.063 | - |
tert-butyloxycarbonyl-Ala-Ala-norvaline-thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 0.106 | - |
tert-butyloxycarbonyl-Ala-Ala-Ala-thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 0.148 | - |
succinyl-Ala-Ala-norvaline-thiobenzyl ester | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.76 | Homo sapiens | - |
healthy | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.76 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.76 | blood | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.76 | additional information | - |
assay methods | Homo sapiens |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 3.4.21.76 | -70°C | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.76 | Succinyl-Ala-Ala-norvaline thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.76 | Tert-Butyloxycarbonyl-Ala-Ala-Ala thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.76 | Tert-Butyloxycarbonyl-Ala-Ala-Ile thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.76 | Tert-Butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
| 3.4.21.76 | Tert-Butyloxycarbonyl-Ala-Ala-norvaline thiobenzyl ester + H2O | best substrate | Homo sapiens | ? | - |
? | |
| 3.4.21.76 | Tert-Butyloxycarbonyl-Ala-Ala-Val thiobenzyl ester + H2O | - |
Homo sapiens | ? | - |
? | |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.4.21.76 | 1.9 | - |
tert-butyloxycarbonyl-Ala-Ala-Ile thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 10.1 | - |
tert-butyloxycarbonyl-Ala-Ala-Ala thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 10.4 | - |
tert-butyloxycarbonyl-Ala-Ala-Val thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 12.2 | - |
tert-butyloxycarbonyl-Ala-Ala-Met thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 19 | - |
Succinyl-Ala-Ala-norvaline thiobenzyl ester | - |
Homo sapiens | |
| 3.4.21.76 | 63.3 | - |
tert-butyloxycarbonyl-Ala-Ala-norvaline thiobenzyl ester | - |
Homo sapiens | |
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