EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.75 | alpha1-antitrypsin | type Pittsburgh as well as wild type | Rattus norvegicus | |
3.4.21.75 | antithrombin | - |
Rattus norvegicus | |
3.4.21.75 | EDTA | - |
Rattus norvegicus | |
3.4.21.75 | EGTA | - |
Rattus norvegicus | |
3.4.21.75 | p-hydroxymercuribenzoate | - |
Rattus norvegicus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
3.4.21.75 | Ca2+ | required | Rattus norvegicus | |
3.4.21.75 | Ca2+ | maximal activity at: 10 mM | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.75 | additional information | Rattus norvegicus | probably plays a role in proprotein maturation | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.4.21.75 | Rattus norvegicus | - |
rat SPC3 cDNA expressed in a mouse L cell line | - |
EC Number | Purification (Comment) | Organism |
---|---|---|
3.4.21.75 | - |
Rattus norvegicus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.4.21.75 | additional information | probably plays a role in proprotein maturation | Rattus norvegicus | ? | - |
? | |
3.4.21.75 | Protein precursor + H2O | circulating human proalbumin variants with a mutation at either of the basic amino acids adjacent to the cleavage site are not cleaved | Rattus norvegicus | ? | - |
? | |
3.4.21.75 | Protein precursor + H2O | cleavage following the prosequence Arg-Gly-Val-Phe-Arg-Arg | Rattus norvegicus | ? | - |
? | |
3.4.21.75 | Protein precursor + H2O | also cleaves chicken proalbumin after a single arginine residue following the Arg-Asn-Leu-Gln-Arg-Phe-Ala-Arg prosequence | Rattus norvegicus | ? | - |
? | |
3.4.21.75 | Protein precursor + H2O | proalbumin (human) | Rattus norvegicus | ? | - |
? | |
3.4.21.75 | Pyr-Arg-Thr-Lys-Arg-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | ? | - |
? | |
3.4.21.75 | tert-butoxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide + H2O | - |
Rattus norvegicus | tert-butoxycarbonyl-Arg-Val-Arg-Arg + 7-amino-4-methylcoumarin | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
3.4.21.75 | More | 3 MW forms: MW 64000, 75000 and 86000, SDS-PAGE, COOH-terminal truncation is responsible for the different molecular mass forms | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.4.21.75 | 6 | - |
tert-butyloxycarbonyl-Arg-Val-Arg-Arg-4-methylcoumarin 7-amide | Rattus norvegicus |