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Literature summary extracted from

  • Plaut, A.G.; Bachovchin, W.W.
    IgA-specific prolyl endopeptidases: serine type (1994), Methods Enzymol., 244, 137-151.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.21.72
-
 Haemophilus influenzae
3.4.21.72
-
 Neisseria gonorrhoeae

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.72 3,4-dichloroisocoumarin
-
 Ureaplasma urealyticum
3.4.21.72 diisopropyl fluorophosphate
-
 Haemophilus influenzae
3.4.21.72 diisopropyl fluorophosphate
-
 Neisseria gonorrhoeae
3.4.21.72 diisopropyl fluorophosphate
-
 Ureaplasma urealyticum
3.4.21.72 Peptide prolyl boronic acids
-
 Haemophilus influenzae
3.4.21.72 Peptide prolyl boronic acids
-
 Neisseria gonorrhoeae

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.72 extracellular
-
 Haemophilus influenzae
-
-
3.4.21.72 extracellular
-
 Neisseria gonorrhoeae
-
-
3.4.21.72 extracellular
-
 Neisseria meningitidis
-
-
3.4.21.72 extracellular
-
 Streptococcus pneumoniae
-
-
3.4.21.72 extracellular
-
 Ureaplasma urealyticum
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.72 immunoglobulin A + H2O Haemophilus influenzae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Neisseria gonorrhoeae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Neisseria meningitidis IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Streptococcus pneumoniae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
 ?
3.4.21.72 immunoglobulin A + H2O Ureaplasma urealyticum IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.72 Haemophilus influenzae
-
-
-
3.4.21.72 Neisseria gonorrhoeae
-
-
-
3.4.21.72 Neisseria meningitidis
-
-
-
3.4.21.72 Streptococcus pneumoniae
-
-
-
3.4.21.72 Ureaplasma urealyticum
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.72 culture medium
-
 Haemophilus influenzae
-
3.4.21.72 culture medium
-
 Neisseria gonorrhoeae
-
3.4.21.72 culture medium
-
 Neisseria meningitidis
-
3.4.21.72 culture medium
-
 Streptococcus pneumoniae
-
3.4.21.72 culture medium
-
 Ureaplasma urealyticum
-

Storage Stability

EC Number Storage Stability Organism
3.4.21.72 4°C, slow loss of activity Haemophilus influenzae
3.4.21.72 4°C, slow loss of activity Neisseria gonorrhoeae
3.4.21.72 4°C, slow loss of activity Neisseria meningitidis
3.4.21.72 4°C, slow loss of activity Streptococcus pneumoniae
3.4.21.72 4°C, slow loss of activity Ureaplasma urealyticum
3.4.21.72 Frozen enzyme is stable for at least 1 year Haemophilus influenzae
3.4.21.72 Frozen enzyme is stable for at least 1 year Neisseria gonorrhoeae
3.4.21.72 Frozen enzyme is stable for at least 1 year Neisseria meningitidis
3.4.21.72 Frozen enzyme is stable for at least 1 year Streptococcus pneumoniae
3.4.21.72 Frozen enzyme is stable for at least 1 year Ureaplasma urealyticum

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.72 Immunoglobulin A + H2O
-
 Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O
-
 Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O
-
 Streptococcus pneumoniae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O
-
 Ureaplasma urealyticum immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 Immunoglobulin A + H2O Haemophilus influenzae enzyme has at least 2 cleavage types. Serogroups, type 1 in serotypes a, b, d, f. Type 2 in c and e Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Haemophilus influenzae ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Neisseria gonorrhoeae ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Neisseria meningitidis ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Streptococcus pneumoniae ?
-
 ?
3.4.21.72 immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Ureaplasma urealyticum ?
-
 ?