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Literature summary extracted from
- Human neutrophil and mast cell proteases implicated in inflammation (1988), Methods Enzymol., 163, 309-327.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.4.21.59 | antipain | - |
Homo sapiens |  |
| 3.4.21.59 | benzamidine | - |
Homo sapiens | |
| 3.4.21.59 | diisopropyl fluorophosphate | - |
Homo sapiens | |
| 3.4.21.59 | leupeptin | - |
Homo sapiens | |
| 3.4.21.59 | additional information | alpha2-macroglobulin; not: alpha1-proteinase inhibitor | Homo sapiens | |
| 3.4.21.59 | N-tosyl-L-Lys chloromethyl ketone | - |
Homo sapiens | |
| 3.4.21.59 | Trypstatin | purification | Homo sapiens |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 3.4.21.59 | 31000 | - |
x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides | Homo sapiens |
| 3.4.21.59 | 33000 | - |
x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides | Homo sapiens |
| 3.4.21.59 | 135000 | 144000 | human | Homo sapiens |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.4.21.59 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.4.21.59 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.4.21.59 | lung | - |
Homo sapiens | - |
| 3.4.21.59 | mast cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.4.21.59 | additional information | the enzyme inactivates fibrinogen and high-molecular weight kininogen and converts C3 to C3a | Homo sapiens | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 3.4.21.59 | tetramer | x * 31000 + x * 33000, human, SDS-PAGE, the enzyme is apparently a noncovalently linked tetramer with two sets of dissimilar, although antigenically related polypeptides | Homo sapiens |
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