Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Koushik, S.V.; Moore III, J.A.; Sundararaju, B.; Phillips, R.S.
    The catalytic mechanism of kynureninase from Pseudomonas fluorescens: Insights from the effects of pH and isotopic substitution on steady-state and pre-steady-state kinetics (1998), Biochemistry, 37, 1376-1382.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.7.1.3 medicine NAD+ biosynthesis Pseudomonas fluorescens
3.7.1.3 medicine tryptophan metabolism Pseudomonas fluorescens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.7.1.3 (4S)-dihydro-L-kynurenine competitive inhibitor Pseudomonas fluorescens
3.7.1.3 anthranilic acid
-
 Pseudomonas fluorescens
3.7.1.3 S-(2-aminophenyl)-L-cysteine S,S-dioxide
-
 Pseudomonas fluorescens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O Pseudomonas fluorescens
-
 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-alanine + pyridoxal 5'-phosphate Pseudomonas fluorescens
-
 pyruvate + pyridoxamine 5'-phosphate
-
 ?
3.7.1.3 L-kynurenine + H2O Pseudomonas fluorescens
-
 anthranilate + L-alanine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.7.1.3 Pseudomonas fluorescens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas fluorescens 3-hydroxyanthranilate + L-alanine
-
 ?
3.7.1.3 3-hydroxy-L-kynurenine + H2O
-
 Pseudomonas fluorescens 3-hydroxyanthranilate + L-Ala
-
 ?
3.7.1.3 L-alanine + pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens pyruvate + pyridoxamine 5'-phosphate
-
 ?
3.7.1.3 L-kynurenine + H2O
-
 Pseudomonas fluorescens anthranilate + L-alanine
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
3.7.1.3 pyridoxal 5'-phosphate
-
 Pseudomonas fluorescens