BRENDA - Enzyme Database

Inducible and constitutive kynureninases. Control of the inducible enzyme activity by transamination and inhibition of the constitutive enzyme by 3-hydroxyanthranilate

Tanizawa, K.; Soda, K.; J. Biochem. 86, 499-508 (1979)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.7.1.3
pyridoxal 5'-phosphate
in the presence of pyruvate
Neurospora crassa
3.7.1.3
pyridoxal 5'-phosphate
-
Sus scrofa
3.7.1.3
pyridoxamine phosphate
in the presence of pyruvate
Neurospora crassa
Application
EC Number
Application
Commentary
Organism
3.7.1.3
medicine
tryptophan metabolism
Sus scrofa
3.7.1.3
medicine
tryptophan metabolism
Neurospora crassa
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.7.1.3
3-Hydroxyanthranilate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
anthranilic acid
-
Neurospora crassa
3.7.1.3
delta-N-acetyl-L-ornithine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
3.7.1.3
Kynurenate
-
Neurospora crassa
3.7.1.3
Kynurenate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
L-alanine
-
Neurospora crassa
3.7.1.3
L-lysine
-
Neurospora crassa
3.7.1.3
L-ornithine
-
Neurospora crassa
3.7.1.3
quinaldinate
-
Neurospora crassa
3.7.1.3
quinaldinate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
S-(beta-aminoethyl)-L-cysteine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.7.1.3
11
-
L-alanine
-
Neurospora crassa
3.7.1.3
40
-
L-ornithine
-
Neurospora crassa
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.7.1.3
105000
-
-
Neurospora crassa
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.7.1.3
L-kynurenine + H2O
Sus scrofa
-
anthranilate + L-alanine
-
Sus scrofa
?
3.7.1.3
L-kynurenine + H2O
Neurospora crassa
-
anthranilate + L-alanine
-
Neurospora crassa
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.7.1.3
Neurospora crassa
-
-
-
3.7.1.3
Sus scrofa
-
-
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
3.7.1.3
12.56
-
-
Neurospora crassa
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.7.1.3
L-kynurenine + H2O
-
289267
Sus scrofa
anthranilate + L-alanine
-
289267
Sus scrofa
?
3.7.1.3
L-kynurenine + H2O
-
289267
Neurospora crassa
anthranilate + L-alanine
-
289267
Neurospora crassa
?
3.7.1.3
L-ornithine + H2O
-
289267
Neurospora crassa
?
-
289267
Neurospora crassa
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.7.1.3
pyridoxal 5'-phosphate
in the presence of pyruvate
Neurospora crassa
3.7.1.3
pyridoxal 5'-phosphate
-
Sus scrofa
3.7.1.3
pyridoxamine phosphate
in the presence of pyruvate
Neurospora crassa
Application (protein specific)
EC Number
Application
Commentary
Organism
3.7.1.3
medicine
tryptophan metabolism
Sus scrofa
3.7.1.3
medicine
tryptophan metabolism
Neurospora crassa
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.7.1.3
3-Hydroxyanthranilate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
anthranilic acid
-
Neurospora crassa
3.7.1.3
delta-N-acetyl-L-ornithine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
3.7.1.3
Kynurenate
-
Neurospora crassa
3.7.1.3
Kynurenate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
L-alanine
-
Neurospora crassa
3.7.1.3
L-lysine
-
Neurospora crassa
3.7.1.3
L-ornithine
-
Neurospora crassa
3.7.1.3
quinaldinate
-
Neurospora crassa
3.7.1.3
quinaldinate
0.001 mM in 0.06 mM Tris-HCl buffer
Sus scrofa
3.7.1.3
S-(beta-aminoethyl)-L-cysteine
0.001 mM in 0.06 mM Tris-HCl buffer
Neurospora crassa
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.7.1.3
11
-
L-alanine
-
Neurospora crassa
3.7.1.3
40
-
L-ornithine
-
Neurospora crassa
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.7.1.3
105000
-
-
Neurospora crassa
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.7.1.3
L-kynurenine + H2O
Sus scrofa
-
anthranilate + L-alanine
-
Sus scrofa
?
3.7.1.3
L-kynurenine + H2O
Neurospora crassa
-
anthranilate + L-alanine
-
Neurospora crassa
?
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
3.7.1.3
12.56
-
-
Neurospora crassa
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.7.1.3
L-kynurenine + H2O
-
289267
Sus scrofa
anthranilate + L-alanine
-
289267
Sus scrofa
?
3.7.1.3
L-kynurenine + H2O
-
289267
Neurospora crassa
anthranilate + L-alanine
-
289267
Neurospora crassa
?
3.7.1.3
L-ornithine + H2O
-
289267
Neurospora crassa
?
-
289267
Neurospora crassa
?