BRENDA - Enzyme Database

A tale of two enzymes, deoxycytidylate deaminase and thymidylate synthase

Maley, F.; Maley, G.F.; Prog. Nucleic Acid Res. Mol. Biol. 39, 49-80 (1990)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCTP
-
Bacillus subtilis
3.5.4.12
dCTP
dCTP promotes an aggregation of enzyme subunits to the active state; positive allosteric effector
Enterobacteria phage T2
3.5.4.12
dCTP
positive allosteric effector
Enterobacteria phage T6
3.5.4.12
dCTP
positive allosteric effector
Equus asinus
3.5.4.12
dCTP
positive allosteric effector
Escherichia virus T4
3.5.4.12
dCTP
activation by dCTP is reversed by addition of dTTP; dCTP promotes an aggregation of enzyme subunits to the active state; positive allosteric effector
Gallus gallus
3.5.4.12
dCTP
-
Herpes simplex virus
3.5.4.12
dCTP
activation by dCTP is reversed by addition of dTTP; positive allosteric effector
Homo sapiens
3.5.4.12
dCTP
positive allosteric effector
Rattus norvegicus
3.5.4.12
dCTP
-
Saccharomyces cerevisiae
Application
EC Number
Application
Commentary
Organism
3.5.4.12
medicine
associated mainly with dividing tissues, potential diagnostic tool for various disease states in which enzyme is elevated
Homo sapiens
3.5.4.12
pharmacology
might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents
Equus asinus
3.5.4.12
pharmacology
enzyme might be a reasonable target for chemotherapeutic agents directed against parasitic as well as neoplastic diseases by limiting the synthesis of dUMP, particularly when used in combination with inhibitors of dTMP synthase or other purine and pyrimidine inhibitors of DNA synthesis
Homo sapiens
Cloned(Commentary)
EC Number
Commentary
Organism
3.5.4.12
-
Escherichia virus T4
Crystallization (Commentary)
EC Number
Crystallization
Organism
3.5.4.12
-
Enterobacteria phage T2
General Stability
EC Number
General Stability
Organism
3.5.4.12
dCTP stabilizes
Gallus gallus
3.5.4.12
dCTP stabilizes
Escherichia virus T4
3.5.4.12
dCTP stabilizes
Enterobacteria phage T2
3.5.4.12
dCTP stabilizing hexameric state, dTTP destabilizing
Equus asinus
3.5.4.12
dCTP stabilizing hexameric state, dTTP destabilizing
Enterobacteria phage T2
3.5.4.12
enzyme is unstable
Gallus gallus
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dTTP
allosteric inhibitor; dTTP favores disaggregated or inhibited state
Enterobacteria phage T2
3.5.4.12
dTTP
allosteric inhibitor
Enterobacteria phage T6
3.5.4.12
dTTP
allosteric inhibitor
Equus asinus
3.5.4.12
dTTP
allosteric inhibitor
Escherichia virus T4
3.5.4.12
dTTP
allosteric inhibitor; dTTP favores disaggregated or inhibited state
Gallus gallus
3.5.4.12
dTTP
-
Herpes simplex virus
3.5.4.12
dTTP
allosteric inhibitor
Homo sapiens
3.5.4.12
dTTP
allosteric inhibitor
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.12
additional information
-
additional information
-
Bacillus subtilis
3.5.4.12
additional information
-
additional information
-
Enterobacteria phage T2
3.5.4.12
additional information
-
additional information
-
Equus asinus
3.5.4.12
additional information
-
additional information
-
Escherichia virus T4
3.5.4.12
additional information
-
additional information
-
Gallus gallus
3.5.4.12
additional information
-
additional information
-
Homo sapiens
3.5.4.12
additional information
-
additional information
-
Rattus norvegicus
3.5.4.12
additional information
-
additional information
-
Saccharomyces cerevisiae
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.5.4.12
20000
-
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Gallus gallus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Bacillus subtilis
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Homo sapiens
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
-
3.5.4.12
dCMP + H2O
Rattus norvegicus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Saccharomyces cerevisiae
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Escherichia virus T4
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Sea urchin
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Equus asinus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Herpes simplex virus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T2
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Macaca mulatta polyomavirus 1
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T6
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Polyomavirus sp.
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Gallus gallus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Bacillus subtilis
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Homo sapiens
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
-
3.5.4.12
dCMP + H2O
Rattus norvegicus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Saccharomyces cerevisiae
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Escherichia virus T4
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Sea urchin
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Equus asinus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Herpes simplex virus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T2
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Macaca mulatta polyomavirus 1
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T6
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Polyomavirus sp.
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
additional information
Homo sapiens
-
?
-
-
-
3.5.4.12
additional information
Escherichia virus T4
function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.12
Bacillus subtilis
-
-
-
3.5.4.12
Enterobacteria phage T2
-
T2-phage infected Escherichia coli; T2r+-infected Escherichia coli B; T2-, T4-, and T6-phage induced enzyme in Escherichia coli
-
3.5.4.12
Enterobacteria phage T6
-
T2-, T4-, and T6-phage induced enzyme in Escherichia coli
-
3.5.4.12
Equus asinus
-
donkey
-
3.5.4.12
Escherichia virus T4
-
T2-, T4-, and T6-phage induced enzyme in Escherichia coli; T4-phage infected Escherichia coli
-
3.5.4.12
Gallus gallus
-
-
-
3.5.4.12
Herpes simplex virus
-
induced by
-
3.5.4.12
Homo sapiens
-
human
-
3.5.4.12
Macaca mulatta polyomavirus 1
-
induced by
-
3.5.4.12
no activity in Escherichia coli
-
enzyme not detectable in Escherichia coli until after infection with T-even bacteriophage; wild type Escherichia coli contains no dCMP deaminase
-
3.5.4.12
no activity in Salmonella typhimurium
-
do not contain dCMP deaminase
-
3.5.4.12
Polyomavirus sp.
-
induced by
-
3.5.4.12
Rattus norvegicus
-
-
-
3.5.4.12
Saccharomyces cerevisiae
-
-
-
3.5.4.12
Sea urchin
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
3.5.4.12
-
Gallus gallus
3.5.4.12
HeLa cells
Homo sapiens
Reaction
EC Number
Reaction
Commentary
Organism
3.5.4.12
dCMP + H2O = dUMP + NH3
highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Bacillus subtilis
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Enterobacteria phage T2
3.5.4.12
dCMP + H2O = dUMP + NH3
highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Enterobacteria phage T6
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Equus asinus
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Escherichia virus T4
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Gallus gallus
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Homo sapiens
3.5.4.12
dCMP + H2O = dUMP + NH3
feedback regulation; highly regulated allosteric enzyme; regulation, allosteric end-product regulation
Rattus norvegicus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
egg
-
Sea urchin
-
3.5.4.12
embryo
-
Gallus gallus
-
3.5.4.12
embryo
-
Rattus norvegicus
-
3.5.4.12
HeLa cell
-
Homo sapiens
-
3.5.4.12
liver
-
Rattus norvegicus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Bacillus subtilis
-
3.5.4.12
additional information
associated mainly with dividing tissues
Enterobacteria phage T2
-
3.5.4.12
additional information
associated mainly with dividing tissues
Enterobacteria phage T6
-
3.5.4.12
additional information
associated mainly with dividing tissues
Equus asinus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Escherichia virus T4
-
3.5.4.12
additional information
associated mainly with dividing tissues
Gallus gallus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Herpes simplex virus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Homo sapiens
-
3.5.4.12
additional information
associated mainly with dividing tissues
Macaca mulatta polyomavirus 1
-
3.5.4.12
additional information
associated mainly with dividing tissues
Polyomavirus sp.
-
3.5.4.12
additional information
associated mainly with dividing tissues
Rattus norvegicus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Saccharomyces cerevisiae
-
3.5.4.12
additional information
associated mainly with dividing tissues
Sea urchin
-
3.5.4.12
spleen
-
Equus asinus
-
3.5.4.12
spleen
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.4.12
500
-
HeLa cells
Homo sapiens
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Equus asinus
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Enterobacteria phage T2
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
very good substrate
289020
Gallus gallus
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
-
289020
Equus asinus
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
very good substrate
289020
Gallus gallus
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
very good substrate
289020
Enterobacteria phage T2
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-Hg-dCMP + H2O
deamination activated by dTTP and inhibited by dCTP
289020
Homo sapiens
5-Hg-dUMP + NH3
-
-
-
?
3.5.4.12
5-Hg-dCMP + H2O
deamination activated by dTTP and inhibited by dCTP
289020
Equus asinus
5-Hg-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Gallus gallus
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Escherichia virus T4
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Equus asinus
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
HeLa cells, good substrate
289020
Homo sapiens
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
-
289020
Gallus gallus
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
-
289020
Equus asinus
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
very poor substrate
289020
Saccharomyces cerevisiae
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
very poor substrate
289020
Enterobacteria phage T2
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Homo sapiens
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Equus asinus
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
very good substrate
289020
Gallus gallus
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
very good substrate
289020
Enterobacteria phage T2
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
-
289020
Gallus gallus
dUMP + NH3
-
289020
Gallus gallus
?
3.5.4.12
dCMP + H2O
-
289020
Bacillus subtilis
dUMP + NH3
-
289020
Bacillus subtilis
?
3.5.4.12
dCMP + H2O
-
289020
Homo sapiens
dUMP + NH3
-
289020
Homo sapiens
-
3.5.4.12
dCMP + H2O
-
289020
Rattus norvegicus
dUMP + NH3
-
289020
Rattus norvegicus
?
3.5.4.12
dCMP + H2O
-
289020
Saccharomyces cerevisiae
dUMP + NH3
-
289020
Saccharomyces cerevisiae
?
3.5.4.12
dCMP + H2O
-
289020
Escherichia virus T4
dUMP + NH3
-
289020
Escherichia virus T4
?
3.5.4.12
dCMP + H2O
-
289020
Sea urchin
dUMP + NH3
-
289020
Sea urchin
?
3.5.4.12
dCMP + H2O
-
289020
Equus asinus
dUMP + NH3
-
289020
Equus asinus
?
3.5.4.12
dCMP + H2O
-
289020
Herpes simplex virus
dUMP + NH3
-
289020
Herpes simplex virus
?
3.5.4.12
dCMP + H2O
-
289020
Enterobacteria phage T2
dUMP + NH3
-
289020
Enterobacteria phage T2
?
3.5.4.12
dCMP + H2O
-
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
289020
Macaca mulatta polyomavirus 1
?
3.5.4.12
dCMP + H2O
-
289020
Enterobacteria phage T6
dUMP + NH3
-
289020
Enterobacteria phage T6
?
3.5.4.12
dCMP + H2O
-
289020
Polyomavirus sp.
dUMP + NH3
-
289020
Polyomavirus sp.
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Gallus gallus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Bacillus subtilis
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Homo sapiens
dUMP + NH3
-
-
-
-
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Rattus norvegicus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Saccharomyces cerevisiae
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Escherichia virus T4
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Sea urchin
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Equus asinus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Herpes simplex virus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Enterobacteria phage T2
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Enterobacteria phage T6
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Polyomavirus sp.
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Gallus gallus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Bacillus subtilis
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Homo sapiens
dUMP + NH3
-
-
-
-
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Rattus norvegicus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Saccharomyces cerevisiae
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Escherichia virus T4
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Sea urchin
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Equus asinus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Herpes simplex virus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Enterobacteria phage T2
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Enterobacteria phage T6
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Polyomavirus sp.
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
-
289020
Homo sapiens
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Gallus gallus
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Bacillus subtilis
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Homo sapiens
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Saccharomyces cerevisiae
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Equus asinus
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Enterobacteria phage T2
?
-
-
-
-
3.5.4.12
additional information
function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants
289020
Escherichia virus T4
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
3.5.4.12
hexamer
6 identical subunits
Enterobacteria phage T2
3.5.4.12
hexamer
6 identical subunits
Enterobacteria phage T6
3.5.4.12
hexamer
6 identical subunits
Equus asinus
3.5.4.12
hexamer
6 identical subunits
Escherichia virus T4
3.5.4.12
hexamer
6 identical subunits
Gallus gallus
3.5.4.12
hexamer
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence; 6 identical subunits
Homo sapiens
3.5.4.12
hexamer
6 identical subunits
Rattus norvegicus
Temperature Optimum [°C]
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.5.4.12
30
-
-
Escherichia virus T4
3.5.4.12
30
-
optimum condition
Homo sapiens
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
3.5.4.12
dCTP
-
Bacillus subtilis
3.5.4.12
dCTP
dCTP promotes an aggregation of enzyme subunits to the active state; positive allosteric effector
Enterobacteria phage T2
3.5.4.12
dCTP
positive allosteric effector
Enterobacteria phage T6
3.5.4.12
dCTP
positive allosteric effector
Equus asinus
3.5.4.12
dCTP
positive allosteric effector
Escherichia virus T4
3.5.4.12
dCTP
activation by dCTP is reversed by addition of dTTP; dCTP promotes an aggregation of enzyme subunits to the active state; positive allosteric effector
Gallus gallus
3.5.4.12
dCTP
-
Herpes simplex virus
3.5.4.12
dCTP
activation by dCTP is reversed by addition of dTTP; positive allosteric effector
Homo sapiens
3.5.4.12
dCTP
positive allosteric effector
Rattus norvegicus
3.5.4.12
dCTP
-
Saccharomyces cerevisiae
Application (protein specific)
EC Number
Application
Commentary
Organism
3.5.4.12
medicine
associated mainly with dividing tissues, potential diagnostic tool for various disease states in which enzyme is elevated
Homo sapiens
3.5.4.12
pharmacology
might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents
Equus asinus
3.5.4.12
pharmacology
enzyme might be a reasonable target for chemotherapeutic agents directed against parasitic as well as neoplastic diseases by limiting the synthesis of dUMP, particularly when used in combination with inhibitors of dTMP synthase or other purine and pyrimidine inhibitors of DNA synthesis
Homo sapiens
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
3.5.4.12
-
Escherichia virus T4
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
3.5.4.12
-
Enterobacteria phage T2
General Stability (protein specific)
EC Number
General Stability
Organism
3.5.4.12
dCTP stabilizes
Gallus gallus
3.5.4.12
dCTP stabilizes
Escherichia virus T4
3.5.4.12
dCTP stabilizes
Enterobacteria phage T2
3.5.4.12
dCTP stabilizing hexameric state, dTTP destabilizing
Equus asinus
3.5.4.12
dCTP stabilizing hexameric state, dTTP destabilizing
Enterobacteria phage T2
3.5.4.12
enzyme is unstable
Gallus gallus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
dTTP
allosteric inhibitor; dTTP favores disaggregated or inhibited state
Enterobacteria phage T2
3.5.4.12
dTTP
allosteric inhibitor
Enterobacteria phage T6
3.5.4.12
dTTP
allosteric inhibitor
Equus asinus
3.5.4.12
dTTP
allosteric inhibitor
Escherichia virus T4
3.5.4.12
dTTP
allosteric inhibitor; dTTP favores disaggregated or inhibited state
Gallus gallus
3.5.4.12
dTTP
-
Herpes simplex virus
3.5.4.12
dTTP
allosteric inhibitor
Homo sapiens
3.5.4.12
dTTP
allosteric inhibitor
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
3.5.4.12
additional information
-
additional information
-
Bacillus subtilis
3.5.4.12
additional information
-
additional information
-
Enterobacteria phage T2
3.5.4.12
additional information
-
additional information
-
Equus asinus
3.5.4.12
additional information
-
additional information
-
Escherichia virus T4
3.5.4.12
additional information
-
additional information
-
Gallus gallus
3.5.4.12
additional information
-
additional information
-
Homo sapiens
3.5.4.12
additional information
-
additional information
-
Rattus norvegicus
3.5.4.12
additional information
-
additional information
-
Saccharomyces cerevisiae
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
3.5.4.12
20000
-
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Gallus gallus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Bacillus subtilis
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Homo sapiens
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
-
3.5.4.12
dCMP + H2O
Rattus norvegicus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Saccharomyces cerevisiae
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Escherichia virus T4
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Sea urchin
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Equus asinus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Herpes simplex virus
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T2
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Macaca mulatta polyomavirus 1
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T6
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Polyomavirus sp.
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Gallus gallus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Bacillus subtilis
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Homo sapiens
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
-
3.5.4.12
dCMP + H2O
Rattus norvegicus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Saccharomyces cerevisiae
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Escherichia virus T4
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Sea urchin
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Equus asinus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Herpes simplex virus
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T2
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Macaca mulatta polyomavirus 1
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Enterobacteria phage T6
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
dCMP + H2O
Polyomavirus sp.
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
dUMP + NH3
-
-
?
3.5.4.12
additional information
Homo sapiens
-
?
-
-
-
3.5.4.12
additional information
Escherichia virus T4
function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants
?
-
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
3.5.4.12
-
Gallus gallus
3.5.4.12
HeLa cells
Homo sapiens
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
egg
-
Sea urchin
-
3.5.4.12
embryo
-
Gallus gallus
-
3.5.4.12
embryo
-
Rattus norvegicus
-
3.5.4.12
HeLa cell
-
Homo sapiens
-
3.5.4.12
liver
-
Rattus norvegicus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Bacillus subtilis
-
3.5.4.12
additional information
associated mainly with dividing tissues
Enterobacteria phage T2
-
3.5.4.12
additional information
associated mainly with dividing tissues
Enterobacteria phage T6
-
3.5.4.12
additional information
associated mainly with dividing tissues
Equus asinus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Escherichia virus T4
-
3.5.4.12
additional information
associated mainly with dividing tissues
Gallus gallus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Herpes simplex virus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Homo sapiens
-
3.5.4.12
additional information
associated mainly with dividing tissues
Macaca mulatta polyomavirus 1
-
3.5.4.12
additional information
associated mainly with dividing tissues
Polyomavirus sp.
-
3.5.4.12
additional information
associated mainly with dividing tissues
Rattus norvegicus
-
3.5.4.12
additional information
associated mainly with dividing tissues
Saccharomyces cerevisiae
-
3.5.4.12
additional information
associated mainly with dividing tissues
Sea urchin
-
3.5.4.12
spleen
-
Equus asinus
-
3.5.4.12
spleen
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
3.5.4.12
500
-
HeLa cells
Homo sapiens
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Equus asinus
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
-
289020
Enterobacteria phage T2
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-bromo-dCMP + H2O
very good substrate
289020
Gallus gallus
5-bromo-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
-
289020
Equus asinus
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
very good substrate
289020
Gallus gallus
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-fluoro-dCMP + H2O
very good substrate
289020
Enterobacteria phage T2
5-fluoro-dUMP + NH3
-
-
-
?
3.5.4.12
5-Hg-dCMP + H2O
deamination activated by dTTP and inhibited by dCTP
289020
Homo sapiens
5-Hg-dUMP + NH3
-
-
-
?
3.5.4.12
5-Hg-dCMP + H2O
deamination activated by dTTP and inhibited by dCTP
289020
Equus asinus
5-Hg-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Gallus gallus
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Escherichia virus T4
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
-
289020
Equus asinus
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-hydroxymethyl-dCMP + H2O
HeLa cells, good substrate
289020
Homo sapiens
5-hydroxymethyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
-
289020
Gallus gallus
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
-
289020
Equus asinus
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
very poor substrate
289020
Saccharomyces cerevisiae
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-iodo-dCMP + H2O
very poor substrate
289020
Enterobacteria phage T2
5-iodo-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Homo sapiens
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Saccharomyces cerevisiae
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
-
289020
Equus asinus
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
very good substrate
289020
Gallus gallus
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
5-methyl-dCMP + H2O
very good substrate
289020
Enterobacteria phage T2
5-methyl-dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
-
289020
Gallus gallus
dUMP + NH3
-
289020
Gallus gallus
?
3.5.4.12
dCMP + H2O
-
289020
Bacillus subtilis
dUMP + NH3
-
289020
Bacillus subtilis
?
3.5.4.12
dCMP + H2O
-
289020
Homo sapiens
dUMP + NH3
-
289020
Homo sapiens
-
3.5.4.12
dCMP + H2O
-
289020
Rattus norvegicus
dUMP + NH3
-
289020
Rattus norvegicus
?
3.5.4.12
dCMP + H2O
-
289020
Saccharomyces cerevisiae
dUMP + NH3
-
289020
Saccharomyces cerevisiae
?
3.5.4.12
dCMP + H2O
-
289020
Escherichia virus T4
dUMP + NH3
-
289020
Escherichia virus T4
?
3.5.4.12
dCMP + H2O
-
289020
Sea urchin
dUMP + NH3
-
289020
Sea urchin
?
3.5.4.12
dCMP + H2O
-
289020
Equus asinus
dUMP + NH3
-
289020
Equus asinus
?
3.5.4.12
dCMP + H2O
-
289020
Herpes simplex virus
dUMP + NH3
-
289020
Herpes simplex virus
?
3.5.4.12
dCMP + H2O
-
289020
Enterobacteria phage T2
dUMP + NH3
-
289020
Enterobacteria phage T2
?
3.5.4.12
dCMP + H2O
-
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
289020
Macaca mulatta polyomavirus 1
?
3.5.4.12
dCMP + H2O
-
289020
Enterobacteria phage T6
dUMP + NH3
-
289020
Enterobacteria phage T6
?
3.5.4.12
dCMP + H2O
-
289020
Polyomavirus sp.
dUMP + NH3
-
289020
Polyomavirus sp.
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Gallus gallus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Bacillus subtilis
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Homo sapiens
dUMP + NH3
-
-
-
-
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Rattus norvegicus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Saccharomyces cerevisiae
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Escherichia virus T4
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Sea urchin
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Equus asinus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Herpes simplex virus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Enterobacteria phage T2
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Enterobacteria phage T6
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
providing an adequate supply of dUMP for formation of dTMP, via dTMP synthase a crucial intermediate for synthesis of DNA
289020
Polyomavirus sp.
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Gallus gallus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Bacillus subtilis
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Homo sapiens
dUMP + NH3
-
-
-
-
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Rattus norvegicus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Saccharomyces cerevisiae
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Escherichia virus T4
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Sea urchin
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Equus asinus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Herpes simplex virus
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Enterobacteria phage T2
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Macaca mulatta polyomavirus 1
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Enterobacteria phage T6
dUMP + NH3
-
-
-
?
3.5.4.12
dCMP + H2O
importance in the generation of dUMP, precursor for synthesis of thymidine nucleotides
289020
Polyomavirus sp.
dUMP + NH3
-
-
-
?
3.5.4.12
additional information
-
289020
Homo sapiens
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Gallus gallus
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Bacillus subtilis
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Homo sapiens
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Saccharomyces cerevisiae
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Equus asinus
?
-
-
-
-
3.5.4.12
additional information
substrate specificity
289020
Enterobacteria phage T2
?
-
-
-
-
3.5.4.12
additional information
function of enzyme is that of enhancing stability of T4-phage multienzyme complex involved in dNTP synthesis, the complex is less stable in cd mutants
289020
Escherichia virus T4
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
3.5.4.12
hexamer
6 identical subunits
Enterobacteria phage T2
3.5.4.12
hexamer
6 identical subunits
Enterobacteria phage T6
3.5.4.12
hexamer
6 identical subunits
Equus asinus
3.5.4.12
hexamer
6 identical subunits
Escherichia virus T4
3.5.4.12
hexamer
6 identical subunits
Gallus gallus
3.5.4.12
hexamer
6 * 20000, HeLa cells, SDS-PAGE and amino acid sequence; 6 identical subunits
Homo sapiens
3.5.4.12
hexamer
6 identical subunits
Rattus norvegicus
Temperature Optimum [°C] (protein specific)
EC Number
Temperature Optimum [°C]
Temperature Optimum Maximum [°C]
Commentary
Organism
3.5.4.12
30
-
-
Escherichia virus T4
3.5.4.12
30
-
optimum condition
Homo sapiens