BRENDA - Enzyme Database

Correlation between deoxycytidine kinase and deaminase activities and response to therapy with ARA-C

Riva, C.M.; Barra, Y.; Cano, J.P.; Tubiana, N.; Lejeune, C.; Merlin, M.; de Sousa, G.; Carcassonne, Y.; Kreis, W.; Lovecchio, J.; Rottachi, C.; Rustum, Y.M.; J. Cell. Pharmacol. 1, 79-85 (1990)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
arabinosylcytosine
ara-C, deactivating dCMP deaminase
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
-
dUMP + NH3
-
Homo sapiens
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
3.5.4.12
Homo sapiens
-
human; patients with acute nonlymphocytic leukemia
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
CCRF-CEM cell
-
Homo sapiens
-
3.5.4.12
KG-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
dCMP + H2O
-
289019
Homo sapiens
dUMP + NH3
-
289019
Homo sapiens
-
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
3.5.4.12
arabinosylcytosine
ara-C, deactivating dCMP deaminase
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
3.5.4.12
dCMP + H2O
Homo sapiens
-
dUMP + NH3
-
Homo sapiens
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
3.5.4.12
CCRF-CEM cell
-
Homo sapiens
-
3.5.4.12
KG-1 cell
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
3.5.4.12
dCMP + H2O
-
289019
Homo sapiens
dUMP + NH3
-
289019
Homo sapiens
-