Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Nucci, R.; Febbraio, F.; Piccialli, G.; de Napoli, L.; Vaccaro, C.; Rossi, M.; Whitehead, E.P.
    Interaction of the high-affinity inhibitor tetrahydro-dUMP with the allosteric enzyme deoxycytidylate aminohydrolase (1994), Arch. Biochem. Biophys., 310, 49-53.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.5.4.12 3,4,5,6-tetrahydro-2'-dUMP high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations Equus asinus
3.5.4.12 dCTP positive allosteric effector Equus asinus

Application

EC Number Application Comment Organism
3.5.4.12 pharmacology might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents Equus asinus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.4.12 3,4,5,6-tetrahydro-2'-deoxyuridine
-
 Equus asinus
3.5.4.12 3,4,5,6-tetrahydro-2'-dUMP high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations Equus asinus
3.5.4.12 additional information kinetics of inhibition; mechanism of inhibition Equus asinus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.4.12 additional information
-
 additional information kinetics of inhibition Equus asinus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.4.12 dCMP + H2O Equus asinus
-
 dUMP + NH3
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.5.4.12 Equus asinus
-
 donkey
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.4.12
-
 Equus asinus

Reaction

EC Number Reaction Comment Organism Reaction ID
3.5.4.12 dCMP + H2O = dUMP + NH3 mechanism Equus asinus
a
3.5.4.12 dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Equus asinus
a
3.5.4.12 dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Equus asinus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.4.12 spleen
-
 Equus asinus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.4.12 dCMP + H2O
-
 Equus asinus dUMP + NH3
-
 ?