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Literature summary extracted from
- Hill coefficient ratios give binding ratios of allosteric enzyme effectors; inhibition, activation, and squatting in deoxycytidylate aminohydrolase (EC 3.5.4.12) (1991), Arch. Biochem. Biophys., 289, 12-18.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.12 | dCTP | positive allosteric effector | Equus asinus |  |
| 3.5.4.12 | additional information | mechanism of activation | Equus asinus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 3.5.4.12 | dTTP | allosteric inhibitor | Equus asinus | |
| 3.5.4.12 | additional information | mechanism of inhibition | Equus asinus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 3.5.4.12 | additional information | - |
additional information | cooperative kinetics, kinetic affinities and effects, mechanism | Equus asinus | |
| 3.5.4.12 | additional information | - |
additional information | steady-state kinetic Hill coefficients, allosteric enzyme kinetic data | Equus asinus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O | Equus asinus | - |
dUMP + NH3 | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 3.5.4.12 | Equus asinus | - |
donkey | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 3.5.4.12 | - |
Equus asinus |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O = dUMP + NH3 | mechanism | Equus asinus | |
| 3.5.4.12 | dCMP + H2O = dUMP + NH3 | regulation, allosteric end-product regulation | Equus asinus | |
| 3.5.4.12 | dCMP + H2O = dUMP + NH3 | highly regulated allosteric enzyme | Equus asinus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 3.5.4.12 | spleen | - |
Equus asinus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 3.5.4.12 | dCMP + H2O | - |
Equus asinus | dUMP + NH3 | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.12 | 37 | - |
assay at | Equus asinus |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 3.5.4.12 | 7.5 | - |
assay at | Equus asinus |
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