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Literature summary extracted from

  • Uttamsingh, V.; Keller, D.A.; Anders, M.W.
    Acylase I-catalyzed deacetylatin of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines (1998), Chem. Res. Toxicol., 11, 801-809.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.5.1.14 medicine N-acetyl-L-cysteine used for drugs against lung disorders and HIV infections, test of potential antitumor agents Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.5.1.14 N-acetyl-L-2-aminohexanoic acid
-
Rattus norvegicus
3.5.1.14 n-butylmalonic acid
-
Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.5.1.14 0.8
-
S-n-propyl-N-acetyl-L-cysteine
-
Rattus norvegicus
3.5.1.14 2.1
-
N-acetyl-L-methionine
-
Rattus norvegicus
3.5.1.14 2.1
-
S-methyl-N-acetyl-L-cysteine
-
Rattus norvegicus
3.5.1.14 3.4
-
S-ethyl-N-acetyl-L-cysteine
-
Rattus norvegicus
3.5.1.14 3.7
-
S-n-butyl-N-acetyl-L-cysteine
-
Rattus norvegicus
3.5.1.14 4
-
N-acetylseleno-L-methionine
-
Rattus norvegicus
3.5.1.14 4.4
-
N-acetyl-L-cysteine
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.5.1.14 cytosol
-
Rattus norvegicus 5829
-
3.5.1.14 cytosol
-
Sus scrofa 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.5.1.14 Co2+
-
Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.5.1.14 43000
-
2 * 43000, SDS-PAGE Rattus norvegicus
3.5.1.14 43000
-
2 * 43000, SDS-PAGE Sus scrofa

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.5.1.14 N-acetyl-L-methionine Homo sapiens
-
L-methionine + acetate
-
?
3.5.1.14 N-acetyl-L-methionine Rattus norvegicus
-
L-methionine + acetate
-
?
3.5.1.14 N-acetyl-L-methionine Sus scrofa
-
L-methionine + acetate
-
?

Organism

EC Number Organism UniProt Comment Textmining
3.5.1.14 Homo sapiens
-
-
-
3.5.1.14 Rattus norvegicus
-
rat, male Sprague-Dawley
-
3.5.1.14 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
3.5.1.14
-
Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.5.1.14 endothelium
-
Homo sapiens
-
3.5.1.14 intestinal mucosa
-
Rattus norvegicus
-
3.5.1.14 intestinal mucosa
-
Sus scrofa
-
3.5.1.14 kidney
-
Rattus norvegicus
-
3.5.1.14 kidney
-
Sus scrofa
-
3.5.1.14 liver
-
Homo sapiens
-
3.5.1.14 liver
-
Rattus norvegicus
-
3.5.1.14 lung
-
Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.5.1.14 N-acetyl-DL-methionine + H2O
-
Homo sapiens DL-methionine + acetate
-
?
3.5.1.14 N-acetyl-DL-methionine + H2O
-
Rattus norvegicus DL-methionine + acetate
-
?
3.5.1.14 N-acetyl-DL-methionine + H2O
-
Sus scrofa DL-methionine + acetate
-
?
3.5.1.14 N-acetyl-L-2-aminopentanoate + H2O
-
Rattus norvegicus acetate + L-2-aminopentanoate
-
?
3.5.1.14 N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + L-cysteine
-
?
3.5.1.14 N-acetyl-L-methionine
-
Homo sapiens L-methionine + acetate
-
?
3.5.1.14 N-acetyl-L-methionine
-
Rattus norvegicus L-methionine + acetate
-
?
3.5.1.14 N-acetyl-L-methionine
-
Sus scrofa L-methionine + acetate
-
?
3.5.1.14 N-acetylseleno-L-methionine + H2O
-
Rattus norvegicus acetate + L-selenomethionine
-
?
3.5.1.14 O-methyl-N-acetyl-DL-serine + H2O
-
Rattus norvegicus acetate + O-methyl-DL-serine
-
?
3.5.1.14 S-(1,1,2,2-tetrafluoroethyl)-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-(-1,1,2,2-terafluoroethyl)-L-cysteine
-
?
3.5.1.14 S-(2-bromo-1,1,2-trifluoroethyl)-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-(2-bromo-1,1,2-trifluoroethyl)-L-cysteine
-
?
3.5.1.14 S-(2-chloro-1,1,2-trifluoroethyl)-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine
-
?
3.5.1.14 S-ethyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-ethyl-L-cysteine
-
?
3.5.1.14 S-isobutyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus ?
-
?
3.5.1.14 S-isopropyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-isopropyl-L-cysteine
-
?
3.5.1.14 S-methyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-methyl-L-cysteine
-
?
3.5.1.14 S-n-butyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-n-butyl-L-cysteine
-
?
3.5.1.14 S-n-propyl-N-acetyl-L-cysteine + H2O
-
Rattus norvegicus acetate + S-n-propyl-L-cysteine
-
?

Subunits

EC Number Subunits Comment Organism
3.5.1.14 dimer 2 * 43000, SDS-PAGE Rattus norvegicus
3.5.1.14 dimer 2 * 43000, SDS-PAGE Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.5.1.14 8
-
-
Sus scrofa