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Literature summary extracted from

  • Pompeo, F.; Van Heijenoort, J.; Mengin-Lecreulx, D.
    Probing the role of cysteine residues in glucosamine-1-phosphate acetyltransferase activity of the bifunctional GlmU protein from Escherichia coli: site-directed mutagenesis and characterization of the mutant enzymes (1998), J. Bacteriol., 180, 4799-4803.
    View publication on PubMedView publication on EuropePMC

General Stability

EC Number General Stability Organism
2.3.1.157 acetyl-CoA protects from inactivation Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.3.1.157 2-Nitro-5-thiocyanobenzoic acid
-
 Escherichia coli
2.3.1.157 DTNB
-
 Escherichia coli
2.3.1.157 iodoacetamide
-
 Escherichia coli
2.3.1.157 N-ethylmaleimide
-
 Escherichia coli
2.3.1.157 p-hydroxymercuribenzoate
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.3.1.157 0.07
-
 D-glucosamine 1-phosphate mutant His6-GlmU C296A Escherichia coli
2.3.1.157 0.09
-
 acetyl-CoA mutant His6-GlmU C307A Escherichia coli
2.3.1.157 0.12
-
 D-glucosamine 1-phosphate mutant His6-GlmU C324A Escherichia coli
2.3.1.157 0.14
-
 acetyl-CoA mutant His6-GlmU C324A Escherichia coli
2.3.1.157 0.15
-
 D-glucosamine 1-phosphate
-
 Escherichia coli
2.3.1.157 0.2
-
 D-glucosamine 1-phosphate mutant His6GlmU Escherichia coli
2.3.1.157 0.2
-
 acetyl-CoA mutant His6GlmU, mutant His6-GlmU C296A, mutant His6-GlmU C385A Escherichia coli
2.3.1.157 0.25
-
 D-glucosamine 1-phosphate mutant His6-GlmU C307A Escherichia coli
2.3.1.157 0.25
-
 acetyl-CoA mutant His6-GlmU C385A Escherichia coli
2.3.1.157 0.6
-
 acetyl-CoA
-
 Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA Bacillus subtilis
-
 N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA Escherichia coli
-
 N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA Neisseria gonorrhoeae
-
 N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA Escherichia coli JM83
-
 N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.3.1.157 Bacillus subtilis
-
-
-
2.3.1.157 Escherichia coli
-
 JM83
-
2.3.1.157 Escherichia coli JM83
-
 JM83
-
2.3.1.157 Neisseria gonorrhoeae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.3.1.157
-
 Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA
-
 Bacillus subtilis N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA
-
 Escherichia coli N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA
-
 Neisseria gonorrhoeae N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 D-glucosamine 1-phosphate + acetyl-CoA
-
 Escherichia coli JM83 N-acetyl-D-glucosamine 1-phosphate + CoA
-
 ?
2.3.1.157 N-acetyl-D-glucosamine 1-phosphate + UTP
-
 Bacillus subtilis UDP-N-acetylglucosamine + ?
-
 ?
2.3.1.157 N-acetyl-D-glucosamine 1-phosphate + UTP glmU gene product, bifunctional enzyme catalyzing 2 subsequent steps in the pathway for UDP-GlcNAc synthesis Escherichia coli UDP-N-acetylglucosamine + ?
-
 r
2.3.1.157 N-acetyl-D-glucosamine 1-phosphate + UTP glmU gene product, bifunctional enzyme catalyzing 2 subsequent steps in the pathway for UDP-GlcNAc synthesis Escherichia coli JM83 UDP-N-acetylglucosamine + ?
-
 r

Synonyms

EC Number Synonyms Comment Organism
2.3.1.157 bifunctional GlmU protein
-
 Escherichia coli
2.3.1.157 GlcNAc-1-P uridyltransferase
-
 Bacillus subtilis
2.3.1.157 GlcNAc-1-P uridyltransferase
-
 Escherichia coli
2.3.1.157 GlcNAc-1-P uridyltransferase
-
 Neisseria gonorrhoeae
2.3.1.157 GlmU enzyme
-
 Escherichia coli