Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Weidner, S.; Kittelmann, M.; Goeke, K.; Ghisalba, O.; Zähner, H.
    3'-Demethoxy-3'hydroxystaurosporine O-methyltransferase from Streptomyces longisporoflavus catalyzing the last step in the biosynthesis of staurosporine (1998), J. Antibiot., 51, 697-682.
No PubMed abstract available

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.1.1.139 tryptophan 2fold increase at 0.2 mM Streptomyces longisporoflavus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.1.1.139 1H-indole 62% activity left at 1.1 mM Streptomyces longisporoflavus
2.1.1.139 3'-demethylstaurosporine 69% activity at 1.1 mM Streptomyces longisporoflavus
2.1.1.139 anthranilate 75% activity left at 1.1 mM Streptomyces longisporoflavus
2.1.1.139 Indole-3-pyruvate 44% activity left at 1.1 mM Streptomyces longisporoflavus
2.1.1.139 S-(5'-adenosyl)-L-homocysteine strong inhibition, 8% activity left at 1.1 mM, probably competitive inhibition Streptomyces longisporoflavus
2.1.1.139 tryptophan 64% activity left at 1.1 mM Streptomyces longisporoflavus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.1.1.139 S-adenosyl-L-methionine + 3'-demethylstaurosporine Streptomyces longisporoflavus
-
S-adenosyl-L-homocysteine + staurosporine
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.139 Streptomyces longisporoflavus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.1.1.139 anion exchange chromatography, partial purification Streptomyces longisporoflavus

Storage Stability

EC Number Storage Stability Organism
2.1.1.139 4°C, 6 days, 80% Streptomyces longisporoflavus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.1.1.139 S-adenosyl-L-methionine + 3'-demethylstaurosporine
-
Streptomyces longisporoflavus S-adenosyl-L-homocysteine + staurosporine
-
?