Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Pritchard, M.P.; Glancey, M.J.; Blake, J.A.R.; Gilham, D.E.; Burchell, B.; Wolf, C.R.; Friedberg, T.
    Functional co-expression of CYP2D6 and human NADPH-cytochrome P450 reductase in Escherichia coli (1998), Pharmacogenetics, 8, 33-42.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.6.2.4 coexpression with two differently modified CYP2D6 cDNAs in Escherichia coli, 17alpha-2D6 + pJR7 and ompA-2D6 + pJR7 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 spheroplast
-
Homo sapiens
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.2.4 0.3 0.7
-
Homo sapiens
1.6.2.4 0.361
-
coexpression of 17alpha-2D6 + pJR7, supplementation of cultures with delta-aminolevulinic acid Homo sapiens
1.6.2.4 0.414
-
coexpression of 17alpha-2D6 + pJR7, without supplementation of cultures with delta-aminolevulinic acid Homo sapiens
1.6.2.4 0.517
-
coexpression of ompA-2D6 + pJR7, supplementation of cultures with delta-aminolevulinic acid Homo sapiens
1.6.2.4 0.601
-
coexpression of ompA-2D6 + pJR7, without supplementation of cultures with delta-aminolevulinic acid Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADPH
-
Homo sapiens 2 ferrocytochrome c + NADP+ + H+
-
?
1.6.2.4 additional information coexpressed with two differently modified CYP2D6 cDNAs in Escherichia coli, functional recombinant monooxygenase, bufuralol and metoprolol metabolism Homo sapiens ?
-
?