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Literature summary extracted from

  • McGuire, J.J.; Anderson, D.J.; McDonald, B.J.; Narayanasami, R.; Bennett, B.M.
    Inhibition of NADPH-Cytochrome P450 Reductase and Glyceryl Trinitrate Biotransformation by Diphenyleneiodonium Sulfate (1998), Biochem. Pharmacol., 56, 881-893.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.6.2.4 diphenylene iodonium sulfate time-dependent and concentration-dependent inhibition of cDNA-expressed liver enzyme as well as aortic and hepatic microsomal enzyme activity Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.6.2.4 0.001 0.003 NADPH
-
Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 microsome 0.03 to 0.1% of aortic microsomal protein Rattus norvegicus
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Rattus norvegicus
-
Sprague-Dawley strain
-
1.6.2.4 Rattus norvegicus Sprague-Dawley
-
Sprague-Dawley strain
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 aorta
-
Rattus norvegicus
-
1.6.2.4 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.6.2.4 0.0104
-
aortic microsomal preparation Rattus norvegicus
1.6.2.4 16.5
-
cDNA-expressed liver enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 2 ferricytochrome c + NADPH additional electron acceptor: cytochrome P450 Rattus norvegicus 2 ferrocytochrome c + NADP+ + H+
-
?
1.6.2.4 2 ferricytochrome c + NADPH additional electron acceptor: cytochrome P450 Rattus norvegicus Sprague-Dawley 2 ferrocytochrome c + NADP+ + H+
-
?
1.6.2.4 additional information denitration of glyceryl trinitrate Rattus norvegicus ?
-
?
1.6.2.4 additional information denitration of glyceryl trinitrate Rattus norvegicus Sprague-Dawley ?
-
?

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.6.2.4 21.3
-
cytochrome c aortic microsomal enzyme Rattus norvegicus
1.6.2.4 21.9
-
cytochrome c purified enzyme Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.2.4 FAD
-
Rattus norvegicus
1.6.2.4 FMN
-
Rattus norvegicus
1.6.2.4 NADPH
-
Rattus norvegicus