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Literature summary extracted from

  • Yoshida, T.; Kikuchi, G.
    Purification and properties of heme oxygenase from rat liver microsomes (1979), J. Biol. Chem., 254, 4487-4491.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.2.4 microsome
-
Sus scrofa
-
-
1.14.14.18 microsome
-
Rattus norvegicus
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.14.18 33000
-
x * 33000, SDS-PAGE Rattus norvegicus
1.14.14.18 200000
-
gel filtration Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.2.4 additional information Sus scrofa microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.6.2.4 Sus scrofa
-
-
-
1.14.14.18 Rattus norvegicus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.14.14.18 2 separate fractions after first DEAE-cellulose, hydroxyapatite, Sephadex G-150, DEAE-cellulose Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.2.4 liver
-
Sus scrofa
-
1.14.14.18 liver
-
Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.14.14.18 additional information
-
-
Rattus norvegicus
1.14.14.18 0.075 0.1 liver heme oxygenase from Co-treated animals, 2 fractions during purification Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.2.4 additional information microsomal heme oxygenase system composed of heme oxygenase and NADPH-cytochrome c reductase catalyzes the oxidative degradation of heme to biliverdin, essential role in the physiological heme catabolism Sus scrofa ?
-
?
1.14.14.18 heme + electron donor + O2 electron donor NADPH Rattus norvegicus biliverdin + Fe2+ + CO + oxidized eletron donor + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.14.14.18 ? x * 33000, SDS-PAGE Rattus norvegicus