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Literature summary extracted from
- A low-molecular-mass protein from Methylococcus capsulatus (Bath) is responsible for the regulation of formaldehyde dehydrogenase activity in vitro (1999), Microbiology, 145, 159-167.
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.46 | 63000 | - |
4 * 63000, ESI-MS | Methylococcus capsulatus |
| 1.2.1.46 | 250000 | - |
gel filtration | Methylococcus capsulatus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.2.1.46 | Methylococcus capsulatus | - |
Bath | - |
| 1.2.1.46 | Methylococcus capsulatus Bath | - |
Bath | - |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.2.1.46 | - |
Methylococcus capsulatus |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.2.1.46 | 234 | - |
- |
Methylococcus capsulatus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.2.1.46 | acetaldehyde + NAD+ + H2O | - |
Methylococcus capsulatus | acetate + NADH + H+ | - |
? |  |
| 1.2.1.46 | acetaldehyde + NAD+ + H2O | - |
Methylococcus capsulatus Bath | acetate + NADH + H+ | - |
? | |
| 1.2.1.46 | formaldehyde + NAD+ + H2O | - |
Methylococcus capsulatus | formate + NADH | - |
? | |
| 1.2.1.46 | formaldehyde + NAD+ + H2O | - |
Methylococcus capsulatus Bath | formate + NADH | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.2.1.46 | tetramer | 4 * 63000, ESI-MS | Methylococcus capsulatus |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.2.1.46 | FDH | - |
Methylococcus capsulatus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.2.1.46 | additional information | substrate specificity is regulated by modifin, FDH oxidizes formaldehyde exclusively and only in the presence of modifin, whereas a range of aldehydes and alcohols are oxidized in the absence of modifin, modifin cannot be replaced by glutathione | Methylococcus capsulatus |
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