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Literature summary extracted from

  • Ford, R.A.; Bhattacharjee, J.K.
    Molecular properties of the lys1+ gene and the regulation of.alpha-aminoadipate reductase in Schizosaccharomyces pombe (1995), Curr. Genet., 28, 131-137.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.2.1.31 two genes, lys1+ and lys7+ are required for the synthesis of the enzyme, some regions of the enzyme sequence are similar to the sequence of Saccharomyces cerevisiae, e.g. Schizosaccharomyces pombe enzyme residues 345 through 385, and 449 through 470 Schizosaccharomyces pombe
1.2.1.95
-
 Schizosaccharomyces pombe

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.2.1.31 L-lysine 20% inhibition at 50 mM Saccharomyces cerevisiae
1.2.1.31 L-lysine 54% inhibition at 1 mM and 80% inhibition at 4 mM Schizosaccharomyces pombe
1.2.1.95 L-lysine enzyme from Schizosaccharomyces pombe is more sensitive to feedback inhibition by lysine in vitro than the enzyme of Saccharomyces cerevisiae Schizosaccharomyces pombe

Organism

EC Number Organism UniProt Comment Textmining
1.2.1.31 Saccharomyces cerevisiae
-
-
-
1.2.1.31 Schizosaccharomyces pombe
-
-
-
1.2.1.95 Schizosaccharomyces pombe P40976
-
-
1.2.1.95 Schizosaccharomyces pombe 972 P40976
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.2.1.31 L-2-aminoadipate + NADPH in presence of ATP + Mg2+ Saccharomyces cerevisiae L-2-aminoadipate 6-semialdehyde + NADP+ + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.2.1.95 Lys1+
-
 Schizosaccharomyces pombe

Expression

EC Number Organism Comment Expression
1.2.1.95 Schizosaccharomyces pombe activity from cells grown in lysine-supplemented minimal or YEPD media is less than the activity of cells grown in minimal medium additional information