EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | Cu2+ | - |
Candida maltosa | |
1.2.1.31 | Fe2+ | - |
Candida maltosa | |
1.2.1.31 | glutamate | competitive inhibitor with respect to alpha-aminoadipate | Candida maltosa | |
1.2.1.31 | Hg2+ | - |
Candida maltosa | |
1.2.1.31 | L-aspartate | competitive inhibitor with respect to alpha-aminoadipate | Candida maltosa | |
1.2.1.31 | Sn2+ | - |
Candida maltosa | |
1.5.1.7 | amino acids | hydrophobic amino acids with 5 or 6 carbon atoms; hydroxylic amino acids | Candida maltosa | |
1.5.1.7 | L-isoleucine | - |
Candida maltosa | |
1.5.1.7 | L-leucine | - |
Candida maltosa | |
1.5.1.7 | L-norleucine | - |
Candida maltosa | |
1.5.1.7 | L-ornithine | - |
Candida maltosa | |
2.3.3.14 | Co2+ | - |
Candida maltosa | |
2.3.3.14 | DL-alpha-aminoadipate | - |
Candida maltosa | |
2.3.3.14 | Hg2+ | - |
Candida maltosa | |
2.3.3.14 | L-Lys | - |
Candida maltosa | |
2.3.3.14 | Mn2+ | - |
Candida maltosa | |
2.3.3.14 | thialysine | L-thialysine | Candida maltosa |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.31 | 0.1 | - |
NADPH | - |
Candida maltosa | |
1.2.1.31 | 0.2 | - |
alpha-aminoadipate | - |
Candida maltosa | |
1.2.1.31 | 0.38 | - |
NADH | - |
Candida maltosa | |
1.2.1.31 | 0.5 | - |
ATP | - |
Candida maltosa | |
1.2.1.31 | 3.8 | - |
MgCl2 | - |
Candida maltosa | |
1.5.1.7 | 0.23 | - |
NADH | - |
Candida maltosa | |
1.5.1.7 | 0.66 | - |
2-oxoglutarate | - |
Candida maltosa | |
1.5.1.7 | 1.6 | - |
L-lysine | - |
Candida maltosa | |
2.3.3.14 | 0.025 | - |
2-oxoglutarate | - |
Candida maltosa | |
2.3.3.14 | 0.033 | - |
acetyl-CoA | - |
Candida maltosa |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | Co2+ | stimulates | Candida maltosa | |
1.2.1.31 | Cu2+ | inhibits | Candida maltosa | |
1.2.1.31 | Mg2+ | stimulates | Candida maltosa | |
1.2.1.31 | Mg2+ | required for activity | Candida maltosa | |
1.2.1.31 | Mn2+ | stimulates | Candida maltosa | |
1.5.1.7 | Cu2+ | 4% of control activity at 1 mM | Candida maltosa | |
1.5.1.7 | Hg2+ | complete inhibition at 1 mM | Candida maltosa | |
1.5.1.7 | Mn2+ | 46% of control activity at 1 mM | Candida maltosa | |
1.5.1.7 | Sn2+ | 11% of control activity at 1 mM | Candida maltosa | |
1.5.1.7 | Zn2+ | 66% of control activity at 1 mM | Candida maltosa |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.2.1.31 | 160000 | - |
gel filtration | Candida maltosa |
1.5.1.7 | 45000 | - |
gel filtration | Candida maltosa |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Candida maltosa | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Candida maltosa | involved in lysine biosynthetic pathway | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Candida maltosa L4 | in presence of ATP and Mg2+ | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | Candida maltosa L4 | involved in lysine biosynthetic pathway | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | Candida maltosa | involved in lysine biosynthesis | L-lysine + 2-oxoglutarate + NADH | - |
? | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | Candida maltosa | last step of alpha-aminoadipate pathway for lysine biosynthesis | L-lysine + 2-oxoglutarate + NADH | - |
? | |
2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate | Candida maltosa | - |
2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.2.1.31 | Candida maltosa | - |
- |
- |
1.5.1.7 | Candida maltosa | - |
- |
- |
1.5.1.7 | Candida maltosa L4 | - |
- |
- |
2.3.3.14 | Candida maltosa | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.2.1.31 | using column chromatography on Sephadex G-25 and Sephadex G-200 | Candida maltosa |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate + CoA | sequential mechanism | Candida maltosa |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.2.1.31 | 0.0063 | - |
5 mM L-lysine as supplement during growth of the enzyme | Candida maltosa |
1.2.1.31 | 0.0072 | - |
no supplement added during growth of the enzyme | Candida maltosa |
1.2.1.31 | 0.0138 | - |
10 mM amitrole as supplement during growth of the enzyme | Candida maltosa |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.2.1.31 | alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Candida maltosa | alpha-aminoadipic acid + NADH + H+ | - |
? | |
1.2.1.31 | alpha-aminoadipic semialdehyde + NAD+ + H2O | - |
Candida maltosa L4 | alpha-aminoadipic acid + NADH + H+ | - |
? | |
1.2.1.31 | L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Candida maltosa | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
1.2.1.31 | L-2-aminoadipate + NADPH | in presence of ATP + Mg2+ | Candida maltosa L4 | L-2-aminoadipate 6-semialdehyde + NADP+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Candida maltosa | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | involved in lysine biosynthetic pathway | Candida maltosa | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | in presence of ATP and Mg2+ | Candida maltosa L4 | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.2.1.31 | L-alpha-aminoadipate + NAD(P)H | involved in lysine biosynthetic pathway | Candida maltosa L4 | L-alpha-aminoadipate-semialdehyde + NAD(P)+ + H2O | - |
? | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | i.e. saccharopine | Candida maltosa | L-lysine + 2-oxoglutarate + NADH | - |
r | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | involved in lysine biosynthesis | Candida maltosa | L-lysine + 2-oxoglutarate + NADH | - |
? | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | last step of alpha-aminoadipate pathway for lysine biosynthesis | Candida maltosa | L-lysine + 2-oxoglutarate + NADH | - |
? | |
1.5.1.7 | N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O | i.e. saccharopine | Candida maltosa L4 | L-lysine + 2-oxoglutarate + NADH | - |
r | |
2.3.3.14 | acetyl-CoA + H2O + 2-oxoglutarate | - |
Candida maltosa | 2-hydroxybutane-1,2,4-tricarboxylate + CoA | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.2.1.31 | 6.5 | 7.5 | - |
Candida maltosa |
1.5.1.7 | 7 | - |
L-lysine + 2-oxoglutarate + NADH | Candida maltosa |
2.3.3.14 | 8 | 8.7 | - |
Candida maltosa |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.2.1.31 | NADH | can replace NADPH with lower activity and higher Km | Candida maltosa | |
1.2.1.31 | NADPH | - |
Candida maltosa | |
1.5.1.7 | NAD+ | - |
Candida maltosa |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.2.1.31 | 1.5 | - |
L-glutamate | - |
Candida maltosa | |
1.2.1.31 | 4.2 | - |
L-aspartate | - |
Candida maltosa | |
2.3.3.14 | 5 | - |
L-lysine | - |
Candida maltosa | |
2.3.3.14 | 5.1 | - |
DL-alpha-aminoadipate | - |
Candida maltosa | |
2.3.3.14 | 15 | - |
L-thialysine | - |
Candida maltosa |