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Literature summary extracted from

  • Pizer, L.I.; Sugimoto, E.
    3-Phosphoglycerate dehydrogenase (Escherichia coli) (1971), Methods Enzymol., 17B, 325-331.
No PubMed abstract available

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
1.1.1.95
-
Escherichia coli

General Stability

EC Number General Stability Organism
1.1.1.95 dithiothreitol increases stability Escherichia coli

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.95 Ag+ inhibition can be overcome by addition of dithiothreitol Escherichia coli
1.1.1.95 L-serine inhibition of enzyme from E. coli, Salmonella typhimurium and Haemophilus influenzae, not of mammalian enzyme, inhibition in both reaction directions Escherichia coli
1.1.1.95 Mercurials inhibition can be overcome by addition of dithiothreitol Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.95 0.0013
-
3-phosphohydroxypyruvate Km at pH 7.5 is lower than at pH 8.8 Escherichia coli
1.1.1.95 0.0078
-
NAD+ Km at pH 7.5 is lower than at pH 8.8 Escherichia coli
1.1.1.95 1.1
-
D-3-phosphoglycerate
-
Escherichia coli

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.95 163000
-
sedimentation equilibrium analysis Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.95 Escherichia coli
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.95
-
Escherichia coli

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.95 additional information
-
-
Escherichia coli

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.95 3-phospho-D-glycerate + NAD+
-
Escherichia coli 3-phosphohydroxypyruvate + NADH
-
?
1.1.1.95 3-phosphoglycerate + NAD+
-
Escherichia coli 3-phosphohydroxypyruvate + NADH
-
r

Subunits

EC Number Subunits Comment Organism
1.1.1.95 tetramer 4 * 40000-50000, sedimentation equilibrium in guanidine-HCl Escherichia coli

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.95 25
-
assay at Escherichia coli

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.95 8.5
-
initial rate maximum, but enzyme not stable Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.95 3-acetylpyridine-NADH 40% as effective as NADH Escherichia coli
1.1.1.95 deamino-NADH as effective as NADH Escherichia coli
1.1.1.95 NAD+
-
Escherichia coli
1.1.1.95 NADH
-
Escherichia coli
1.1.1.95 NADPH 8% as effective as NADH Escherichia coli