Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Jordan-Starck, T.C.; Rodwell, V.W.
    Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA reductase. Characterization and chemical modification (1989), J. Biol. Chem., 264, 17913-17918.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.1.1.88 CoA mevaldehyde reduction Pseudomonas mevalonii
1.1.1.88 pantetheine mevaldehyde reduction Pseudomonas mevalonii

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.88 expressed in Escherichia coli Pseudomonas mevalonii

General Stability

EC Number General Stability Organism
1.1.1.88 20 mM N-ethylmaleimide, 50 min, 12% activity Pseudomonas mevalonii

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.88 0.05
-
CoASH oxidative acylation of mevalonate Pseudomonas mevalonii
1.1.1.88 0.17
-
NADH reductive deacylation to mevalonate Pseudomonas mevalonii
1.1.1.88 0.17
-
NAD+ mevaldate oxidation Pseudomonas mevalonii
1.1.1.88 0.22
-
mevalonate oxidative acylation of mevalonate Pseudomonas mevalonii
1.1.1.88 0.3
-
DL-3-hydroxy-3-methylglutaryl-CoA reductive deacylation to mevalonate Pseudomonas mevalonii
1.1.1.88 0.37
-
NAD+ oxidative acylation of mevalonate Pseudomonas mevalonii
1.1.1.88 1.36
-
DL-mevaldate mevaldate oxidation Pseudomonas mevalonii
1.1.1.88 36
-
DL-mevaldate mevaldate reduction to mevalonate Pseudomonas mevalonii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.88 cytosol
-
Pseudomonas mevalonii 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.88 Pseudomonas mevalonii
-
formerly Pseudomonas sp. M
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.88
-
Pseudomonas mevalonii

Storage Stability

EC Number Storage Stability Organism
1.1.1.88 -180°C, 400 mM KCl, 12 months Pseudomonas mevalonii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.88 (R)-mevalonate + CoA + 2 NAD+
-
Pseudomonas mevalonii (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H+
-
r
1.1.1.88 3-hydroxy-3-methylglutaryl-CoA + NADH + H+
-
Pseudomonas mevalonii mevalonate + CoA + NAD+
-
?
1.1.1.88 DL-mevaldate + CoA + NAD+
-
Pseudomonas mevalonii 3-hydroxy-3-methylglutaryl-CoA NADH + H+
-
r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.88 NAD+
-
Pseudomonas mevalonii
1.1.1.88 NADH reverse reaction Pseudomonas mevalonii