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Literature summary extracted from

  • Hara, A.; Nakayama, T.; Nakagawa, M.; Inoue, Y.; Tanabe, H.; Sawada, H.
    Kinetic and stereochemical studies on reaction mechanism of mouse liver 17beta-hydroxysteroid dehydrogenases (1987), J. Biochem., 102, 1585-1592.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.64 cytosol
-
 Mus musculus 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.64 17beta-estradiol + NADP+ Mus musculus
-
 estrone + NADPH
-
 r
1.1.1.64 5beta-androstane-3alpha,17beta-diol + NADP+ Mus musculus
-
 5beta-androstane-3alpha-ol-17-one + NADPH + H+
-
 r
1.1.1.64 testosterone + NADP+ Mus musculus
-
 androst-4-ene-3,17-dione + NADPH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Mus musculus
-
-
-
1.1.1.64 Mus musculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.62 17beta-estradiol + NAD(P)+ = estrone + NAD(P)H + H+ ordered bi bi mechanism Mus musculus
a
1.1.1.64 testosterone + NADP+ = androstenedione + NADPH + H+ 4-pro-R-hydrogen atom of NADPH is transferred to the alpha-face of the steroid molecule Mus musculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 liver
-
 Mus musculus
-
1.1.1.64 liver
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 estradiol-17beta + NADP+
-
 Mus musculus estrone + NADPH
-
 ?
1.1.1.62 estradiol-17beta + NADP+
-
 Mus musculus estrone + NADPH
-
 r
1.1.1.64 17beta-estradiol + NADP+
-
 Mus musculus estrone + NADPH
-
 r
1.1.1.64 5beta-androstane-3alpha,17beta-diol + NADP+
-
 Mus musculus 5beta-androstane-3alpha-ol-17-one + NADPH + H+
-
 r
1.1.1.64 testosterone + NADP+
-
 Mus musculus androst-4-ene-3,17-dione + NADPH + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NADP+ cofactor Mus musculus
1.1.1.64 NADP+
-
 Mus musculus