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Literature summary extracted from

  • Pollow, K.; Luebbert, H.; Jeske, R.; Pollow, B.
    Studies on 17beta-hydroxysteroid dehydrogenase in human endometrium and endometrial carcinoma (1975), Acta Endocrinol., 79, 146-156.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.62 0.0033
-
 estradiol-17beta
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.62 cytoplasm
-
 Homo sapiens 5737
-

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.62 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.62 uterine endometrium secretory Homo sapiens
-
1.1.1.62 uterine endometrium endometrial carcinoma Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.62 androstenedione + NADPH + H+
-
 Homo sapiens testosterone + NADP+
-
 r
1.1.1.62 estradiol-17beta + NAD+
-
 Homo sapiens estrone + NADH
-
 r
1.1.1.62 estradiol-17beta + NADP+ maximal activity with NADP+ is approximately 1/3 of that with NAD+ Homo sapiens estrone + NADPH
-
 r
1.1.1.62 estrone + NADH
-
 Homo sapiens estradiol-17beta + NAD+
-
 r
1.1.1.62 estrone + NADPH + H+
-
 Homo sapiens estradiol-17beta + NADP+
-
 r
1.1.1.62 testosterone + NADP+
-
 Homo sapiens 4-androstene-3,17-dione + NADPH + H+ androstenedione r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.1.1.62 40
-
 oxidation of estradiol-17beta Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.1.1.62 additional information
-
 enzyme is cold sensitive, cold inactivation is reduced by NAD+, NADP+, estradiol or glycerol Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.1.1.62 6
-
 reduction of estrone Homo sapiens
1.1.1.62 9.5
-
 oxidation of estradiol-17beta Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.62 NAD+ cofactor Homo sapiens
1.1.1.62 NAD+ maximal activity with NADP+ is approximately 1/3 of that with NAD+ Homo sapiens
1.1.1.62 NADH cofactor Homo sapiens
1.1.1.62 NADP+ cofactor Homo sapiens
1.1.1.62 NADP+ maximal activity with NADP+ is approximately 1/3 of that with NAD+ Homo sapiens
1.1.1.62 NADPH cofactor Homo sapiens