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Literature summary extracted from

  • Tanaka, M.; Ohno, S.; Adachi, S.; Nakajin, S.; Shinoda, M.; Nagahama, Y.
    Pig testicular 20beta-hydroxysteroid dehydrogenase exhibits carbonyl reductase-like structure and activity (1992), J. Biol. Chem., 267, 13451-13455.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.53 85% amino acid sequence homology with human carbonyl reductase Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.53 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.53
-
 Sus scrofa

Reaction

EC Number Reaction Comment Organism Reaction ID
1.1.1.53 androstan-3alpha,17beta-diol + NAD+ = 17beta-hydroxyandrostan-3-one + NADH + H+ exhibits carbonyl reductase-like activity, 85% amino acid sequence homology with human carbonyl reductase Sus scrofa
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.53 testis
-
 Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.1.1.53 0.038
-
 NADPH, phenylglyoxal Sus scrofa
1.1.1.53 0.039
-
 NADPH, 5alpha-dihydrotestosterone Sus scrofa
1.1.1.53 0.039
-
 NADPH, 5beta-dihydrotestosterone Sus scrofa
1.1.1.53 0.042
-
 NADPH, cyclohexanone Sus scrofa
1.1.1.53 0.043
-
 NADPH, 4-nitrobenzaldehyde Sus scrofa
1.1.1.53 0.045
-
 NADPH, camphorquinone Sus scrofa
1.1.1.53 0.123
-
 NADPH, methylglyoxal Sus scrofa
1.1.1.53 0.157
-
 NADPH, phenanthrenequinone Sus scrofa
1.1.1.53 0.167
-
 NADPH, hydrindantin Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.53 17alpha-hydroxyprogesterone + NADPH + H+
-
 Sus scrofa 17alpha,20beta-dihydroxy-pregn-4-ene-3-one + NADP+
-
 ?
1.1.1.53 4-nitrobenzaldehyde + NADPH
-
 Sus scrofa ?
-
 ?
1.1.1.53 5alpha-androstan-17beta-ol-3-one + NAD(P)H + H+ i.e. 5alpha-dihydrotestosterone Sus scrofa 5alpha-androstan-3alpha,17beta-diol + NAD(P)+
-
 ?
1.1.1.53 5beta-androstan-17beta-ol-3-one + NAD(P)H i.e. 5beta-dihydrotestosterone Sus scrofa ?
-
 ?
1.1.1.53 9,10-phenanthrenequinone + NADPH
-
 Sus scrofa ?
-
 ?
1.1.1.53 camphorquinone + NADPH + H+
-
 Sus scrofa camphorquinol + NADP+
-
 ?
1.1.1.53 cyclohexanone + NADPH
-
 Sus scrofa cyclohexanol + NADP+
-
 ?
1.1.1.53 hydrindantin + NADPH
-
 Sus scrofa ?
-
 ?
1.1.1.53 methylglyoxal + NADPH
-
 Sus scrofa ?
-
 ?
1.1.1.53 additional information enzyme cannot catalyze the reduction of 11-hydroxy- or 11-oxo-C21-steroids, i.e. cortisol, corticosterone, cortisone Sus scrofa ?
-
 ?
1.1.1.53 phenylglyoxal + NADPH
-
 Sus scrofa ?
-
 ?
1.1.1.53 progesterone + NAD(P)H
-
 Sus scrofa 20beta-hydroxy-pregn-4-ene-3-one + NAD(P)+
-
 ?