Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Mulder, E.; Lamers-Stahlhofen, G.J.M.; van der Molen, H.J.
    Isolation and characterization of 17beta-hydroxy steroid dehydrogenase from human erythrocytes (1972), Biochem. J., 127, 649-659.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.51 albumin
-
 Homo sapiens
1.1.1.51 chloromercuribenzene-p-sulfonic acid
-
 Homo sapiens
1.1.1.51 p-chloromercuribenzoate
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.1.1.51 0.17
-
 testosterone
-
 Homo sapiens
1.1.1.51 0.24
-
 testosterone NADP+ as variable substrate Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.51 cytosol
-
 Homo sapiens 5829
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.1.1.51 64000
-
 gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.51 17-oxo steroids + NADPH Homo sapiens maintenance of balance between oxidized and reduced steroids in blood ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.51 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.51 partial Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.1.1.51 erythrocyte
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
1.1.1.51 -15°C, a few percent loss of activity in several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.51 17-oxo steroids + NADPH maintenance of balance between oxidized and reduced steroids in blood Homo sapiens ?
-
 ?
1.1.1.51 20alpha-hydroxypregn-4-en-3-one + NADP+
-
 Homo sapiens progesterone + NADPH
-
 r
1.1.1.51 androst-5-ene-3beta,17beta-diol + NADP+
-
 Homo sapiens dehydroepiandrosterone + NADPH
-
 r
1.1.1.51 estradiol + NADP+
-
 Homo sapiens estrone + NADPH
-
 r
1.1.1.51 estradiol sulfate + NADP+
-
 Homo sapiens estrone sulfate + NADPH
-
 ?
1.1.1.51 testosterone + NAD(P)+
-
 Homo sapiens androst-4-en-3,17-dione + NAD(P)H + H+
-
 r

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.51 NADP+ specific for Homo sapiens
1.1.1.51 NADPH specific for Homo sapiens